Interplay between long non-coding RNAs and microRNAs in cancer
Autor: | Francesco Russo (1), Giulia Fiscon (2), Federica Conte (2), Milena Rizzo (3, Paola Paci (2), Marco Pellegrini (5) |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Long noncoding RNA-derived microRNAs Computational biology Biology Long noncoding RNAs sponge long non-coding RNA-derived microRNAs 03 medical and health sciences long non-coding RNAs Intergenic region microRNA Gene expression medicine cancer Gene Protein coding Biological Networks host genes Competing endogenous RNA Cancer medicine.disease Competing endogenous RNAs Host genes MicroRNAs Sponge microRNAs 030104 developmental biology competing endogenous RNAs Human breast |
Zdroj: | Computational Cell Biology: Methods and Protocols, pp. 75–92, 2018 info:cnr-pdr/source/autori:Francesco Russo (1), Giulia Fiscon (2), Federica Conte (2), Milena Rizzo (3,4), Paola Paci (2), Marco Pellegrini (5)/titolo:Interplay between long non-coding RNAs and microRNAs in cancer/titolo_volume:Computational Cell Biology: Methods and Protocols/curatori_volume:/editore:/anno:2018 Methods in Molecular Biology ISBN: 9781493986170 |
Popis: | In the last decade noncoding RNAs (ncRNAs) have been extensively studied in several biological processes and human diseases including cancer. microRNAs (miRNAs) are the best-known class of ncRNAs. miRNAs are small ncRNAs of around 20-22 nucleotides (nt) and are crucial posttranscriptional regulators of protein coding genes. Recently, new classes of ncRNAs, longer than miRNAs have been discovered. Those include intergenic noncoding RNAs (lincRNAs) and circular RNAs (circRNAs). These novel types of ncRNAs opened a very exciting field in biology, leading researchers to discover new relationships between miRNAs and long noncoding RNAs (lncRNAs), which act together to control protein coding gene expression. One of these new discoveries led to the formulation of the "competing endogenous RNA (ceRNA) hypothesis." This hypothesis suggests that an lncRNA acts as a sponge for miRNAs reducing their expression and causing the upregulation of miRNA targets. In this chapter we first discuss some recent discoveries in this field showing the mutual regulation of miRNAs, lncRNAs, and protein-coding genes in cancer. We then discuss the general approaches for the study of ceRNAs and present in more detail a recent computational approach to explore the ability of lncRNAs to act as ceRNAs in human breast cancer that has been shown to be, among the others, the most precise and promising. |
Databáze: | OpenAIRE |
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