Evolution of platelet functions in cirrhotic patients undergoing liver transplantation: A prospective exploration over a month

Autor: Sébastien Bertil, Corinne Vezinet, Pascale Gaussem, Louis Puybasset, Jean Szymezak, Christilla Bachelot-Loza, Yann Loncar, Jean-Christophe Vaillant, Benjamin Granger, David M. Smadja, Ludovic Suner, Dominique Helley, Pascal Lebray, Ovidiu Gostian, Axelle Dupont, Daniel Eyraud
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Liver Cirrhosis
Male
P-selectin
Platelet Aggregation
Physiology
medicine.medical_treatment
lcsh:Medicine
Liver transplantation
Cardiovascular Medicine
Pathology and Laboratory Medicine
Gastroenterology
Vascular Medicine
0302 clinical medicine
Animal Cells
Medicine and Health Sciences
Platelet
Prospective Studies
Prospective cohort study
lcsh:Science
Multidisciplinary
Liver Diseases
Liver Neoplasms
Hematology
Middle Aged
Thrombosis
Body Fluids
P-Selectin
Blood
Cirrhosis
Liver
Cardiovascular Diseases
030220 oncology & carcinogenesis
Hepatocellular carcinoma
030211 gastroenterology & hepatology
Female
Anatomy
Cellular Types
Research Article
Platelets
Blood Platelets
medicine.medical_specialty
Carcinoma
Hepatocellular
Platelet Function Tests
CD40 Ligand
Surgical and Invasive Medical Procedures
Hemorrhage
Gastroenterology and Hepatology
Blood Plasma
03 medical and health sciences
Digestive System Procedures
Signs and Symptoms
Diagnostic Medicine
Internal medicine
medicine
Humans
Platelet activation
Blood Coagulation
Transplantation
Blood Cells
Coagulation Disorders
business.industry
Platelet Count
lcsh:R
Biology and Life Sciences
Cell Biology
Organ Transplantation
medicine.disease
Platelet Activation
Liver Transplantation
Concomitant
lcsh:Q
business
Zdroj: PLoS ONE, Vol 13, Iss 8, p e0200364 (2018)
PLoS ONE
ISSN: 1932-6203
Popis: This prospective observational study was designed to analyze platelet functions across time in 50 patients scheduled for liver transplantation (LT) secondary to decompensated cirrhosis or hepatocellular carcinoma. Platelet functions were assessed before LT (pre-LT), one week (D7) and 1 month (D28) after LT. Platelet count significantly increased from pre-LT time to day 28 as well as circulating CD34+hematopoietic stem cells. To avoid any influence of platelet count on assays, platelet function was evaluated on platelet-rich-plasma adjusted to pre-LT platelet count. Although platelet secretion potential did not differ between time-points, as evaluated by the expression of CD62P upon strong activation, platelet aggregation in response to various agonists significantly increased along time, however with no concomitant increase of circulating markers of platelet activation: platelet microvesicles, platelet-leukocyte complexes, soluble CD40L and soluble CD62P. In the multivariate analysis, hepatic function was associated with platelet count and function. A lower platelet aggregation recovery was correlated with Child C score. History of thrombosis or bleeding was associated with respective higher or lower values of platelet aggregation. This longitudinal analysis of platelet functions in LT patients showed an improvement of platelet functions along time together with platelet count increase, with no evidence of platelet hyperactivation at any time-point.
Databáze: OpenAIRE
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