The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables

Autor:	Paul R. Lichter, Douglas E. Gaasterland, David S. Friedman, Joshua D. Stein, Brian L. Yaspan, Yutao Liu, Frank W. Rozsa, Felipe A. Medeiros, Joel S. Schuman, Douglas Vollrath, Robert N. Weinreb, Stephanie Loomis, Gadi Wollstein, Jae H. Kang, Richard K. Lee, Louis R. Pasquale, Jonathan L. Haines, Sachiko Yoneyama, Kuldev Singh, Michael A. Hauser, Lana M. Olson, Anthony Realini, Wael Abdrabou, Catherine A. McCarty, E. DelBono, Donald L. Budenz, Margaret A. Pericak-Vance, Donald J. Zack, Julia E. Richards, Janey L. Wiggs, Sayoko E. Moroi, Robert Rand Allingham, Kang Zhang, Terry Gaasterland
Rok vydání:	2013
Předmět:	Research design Adult Male Aging Clinical variables primary open-angle glaucoma genetic structures Open angle glaucoma Genotype Clinical Sciences MEDLINE Genome-wide association study Trabeculectomy and over Neurodegenerative Bioinformatics Ophthalmology & Optometry Article 80 and over Genetics Medicine Humans Genetic Predisposition to Disease Cooperative Behavior Eye Disease and Disorders of Vision Antihypertensive Agents Intraocular Pressure Genetic association Aged Aged 80 and over genome-wide association study business.industry Gene Expression Profiling Human Genome Case-control study Neurosciences Glaucoma Middle Aged eye diseases Gene expression profiling Ophthalmology Open-Angle Research Design Case-Control Studies Female sense organs business Glaucoma Open-Angle Genome-Wide Association Study
Zdroj:	Journal of glaucoma, vol 22, iss 7
Popis:	Primary open-angle glaucoma (POAG) is a common disease with complex inheritance. The identification of genes predisposing to POAG is an important step toward the development of novel gene-based methods of diagnosis and treatment. Genome-wide association studies (GWAS) have successfully identified genes contributing to complex traits such as POAG however, such studies frequently require very large sample sizes, and thus, collaborations and consortia have been of critical importance for the GWAS approach. In this report we describe the formation of the NEIGHBOR consortium, the harmonized case control definitions used for a POAG GWAS, the clinical features of the cases and controls, and the rationale for the GWAS study design.
Databáze:	OpenAIRE
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