The roles of tobacco, alcohol, and diet in the etiology of upper alimentary and respiratory tract cancers
| Autor: | Stephen S. Hecht, G. David McCoy, Ernst L. Wynder |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Vitamin
Risk medicine.medical_specialty Nicotine Nitrosamines Alcohol Drinking Esophageal Neoplasms Epidemiology Gastroenterology chemistry.chemical_compound Internal medicine Cricetinae medicine Animals Humans Laryngeal Neoplasms Carcinogen Environmental Carcinogen business.industry Smoking Public Health Environmental and Occupational Health N-Nitrosopyrrolidine Cancer Micronutrient medicine.disease Diet Malnutrition medicine.anatomical_structure chemistry Liver Etiology Mouth Neoplasms business Respiratory tract |
| Zdroj: | Preventive medicine. 9(5) |
| ISSN: | 0091-7435 |
| Popis: | This paper reviews the epidemiological evidence associating alcohol and tobacco consumption as well as diet as risk factors for upper alimentary and respiratory tract cancer. The possible association of alcohol-related nutritional deficiencies (especially zinc and vitamin A) in this process is discussed. Experimental studies on the metabolism and carcinogenicity of N -nitrosopyrrolidine (NPYR) and N ′-nitrosonornicotine (NNN), two cyclic nitrosamines which are potential environmental carcinogens, are presented, and it is shown that microsomes isolated from hamsters consuming ethanol are able to perform the initial metabolic step (α-hydroxylation) at greater rates than similar preparations from control animals. We conclude that increased attention should be paid to the possibility that alcohol-related deficiencies in micronutrients are a contributing factor in the etiology of upper alimentary and respiratory tract cancers. |
| Databáze: | OpenAIRE |
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