C-reactive protein +1444CT (rs1130864) genetic polymorphism is associated with the susceptibility to systemic lupus erythematosus and C-reactive protein levels
| Autor: | Marcell Allyson Batisti Lozovoy, Isaias Dichi, Tamires Flauzino, Nicole Perugini Stadtlober, Francieli Delongui, Tatiana Mayiumi Veiga Iriyoda, Neide Tomimura Costa, Andréa Name Colado Simão, Daniela Frizon Alfieri, Edna Maria Vissoci Reiche |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype 030204 cardiovascular system & hematology Polymorphism Single Nucleotide Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Rheumatology Gene Frequency Internal medicine Medicine Humans Lupus Erythematosus Systemic Genetic Predisposition to Disease Allele skin and connective tissue diseases Allele frequency Alleles Genetic Association Studies 030203 arthritis & rheumatology biology business.industry C-reactive protein General Medicine Odds ratio C-Reactive Protein Immunology biology.protein Female Restriction fragment length polymorphism business Body mass index |
| Zdroj: | Clinical rheumatology. 36(8) |
| ISSN: | 1434-9949 |
| Popis: | The T rare allele of +1444CT (rs1130864) polymorphism of C-reactive protein (CRP) has been associated with increased CRP levels in some inflammatory conditions, but its role on systemic lupus erythematosus (SLE) susceptibility and on CRP levels in SLE patients remains uncertain. The objective of the study was to evaluate the association between the rs1130864 CRP polymorphism with SLE susceptibility, disease activity, and CRP levels in SLE Brazilian patients. The study enrolled 176 SLE patients and 137 controls. SLE disease activity was assessed using the SLE Disease Activity Index (SLEDAI). The rs1130864 CRP polymorphism was determined using polymerase chain reaction and restriction fragment length polymorphism. SLE patients presented higher body mass index (p = 0.046) and CRP levels (p = 0.017) than controls. The genotype and allele frequencies of patients differed from controls [CC vs. CT = odds ratio (OR) 1.730, 95% confidence interval (CI) 1.068–2.803, p = 0.035; CC vs. TT = OR 3.667, 95% CI 1.410–9.533, p = 0.009; C vs. T = OR 1.883, 95% CI 1.299–2.728, p = 0.001)]. Patients carrying the T allele presented higher CRP levels (p = 0.009), were more frequent Caucasians (p = 0.018), and with no use of immunosuppressive treatment (p = 0.004) than those carrying the C allele. However, the SLEDAI and anti-double-stranded DNA positivity did not differ from those carrying T vs. C allele (p = 0.595 and p = 0.243, respectively). The rs1130864 CRP polymorphism was associated with SLE susceptibility and CRP levels, but not with disease activity, suggesting that this polymorphism may play a role in the pathophysiology of SLE through increasing the CRP that, probably, plays an inflammatory role in SLE pathophysiology. |
| Databáze: | OpenAIRE |
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