Changes in endothelial cell proliferation and vascular permeability after systemic lipopolysaccharide administration in the subfornical organ

Autor: Ayami Isonishi, Kouko Tatsumi, Shoko Morita-Takemura, Hiroaki Okuda, Tatsuhide Tanaka, Kazuki Nakahara, Akio Wanaka
Rok vydání: 2016
Předmět:
Lipopolysaccharides
Male
0301 basic medicine
medicine.medical_specialty
Time Factors
Lipopolysaccharide
Angiogenesis
Green Fluorescent Proteins
Immunology
Inflammation
Vascular permeability
Biology
Blood–brain barrier
Capillary Permeability
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Animals
Immunology and Allergy
Cell Proliferation
Microscopy
Confocal
Endothelial Cells
Membrane Proteins
Subfornical organ
Mice
Inbred C57BL
Platelet Endothelial Cell Adhesion Molecule-1
Endothelial stem cell
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Bromodeoxyuridine
Neurology
chemistry
Systemic administration
Neurology (clinical)
medicine.symptom
Carrier Proteins
030217 neurology & neurosurgery
Subfornical Organ
Zdroj: Journal of Neuroimmunology. 298:132-137
ISSN: 0165-5728
DOI: 10.1016/j.jneuroim.2016.06.011
Popis: The subfornical organ (SFO) has highly permeable fenestrated vasculature and is a key site for immune-to-brain communications. Recently, we showed the occurrence of continuous angiogenesis in the SFO. In the present study, we found that systemic administration of bacterial lipopolysaccharide (LPS) reduced the vascular permeability and endothelial cell proliferation. In LPS-administered mice, the SFO vasculature showed a significant decrease in the immunoreactivity of plasmalemma vesicle associated protein-1, a marker of endothelial fenestral diaphragms. These data suggest that vasculature undergoes structural change to decrease vascular permeability in response to systemic LPS administration.
Databáze: OpenAIRE
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