EPA/DHA and vitamin A supplementation improves spatial memory and alleviates the age-related decrease in hippocampal RXRγ and kinase expression in rats
| Autor: | Anne Létondor, Emmanuel Richard, Serge Alfos, Sophie Layé, Benjamin Buaud, Carole Vaysse, Véronique Pallet |
|---|---|
| Přispěvatelé: | Nutrition et Neurobiologie intégrée (NutriNeuro), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, Institut Polytechnique de Bordeaux (Bordeaux INP), Institut des corps gras (ITERG), Institut National de la Santé et de la Recherche Médicale (INSERM), ProdInra, Migration, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Vitamin Aging medicine.medical_specialty medicine.drug_class Cognitive Neuroscience [SDV]Life Sciences [q-bio] Retinoic acid Morris water navigation task Biology Hippocampus lcsh:RC321-571 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ca2+/calmodulin-dependent protein kinase Internal medicine medicine vieillissement cerebral rat vitamine a Retinoid n-3 long-chain PUFA vitamin A spatial memory hippocampus kinases retinoid receptors Vitamin A Protein kinase B lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Original Research récepteur nucléaire 2. Zero hunger acide eicosapentaénoique Retinoid receptors acide docosahexaénoique Eicosapentaenoic acid [SDV] Life Sciences [q-bio] 030104 developmental biology Endocrinology chemistry Docosahexaenoic acid cerveau lipids (amino acids peptides and proteins) retinoide 030217 neurology & neurosurgery Neuroscience expression des gènes |
| Zdroj: | Frontiers in Aging Neuroscience, Vol 8 (2016) Frontiers in Aging Neuroscience Frontiers in Aging Neuroscience, Frontiers, 2016, 8, 16 p. ⟨10.3389/fnagi.2016.00103⟩ Frontiers in Aging Neuroscience (8), 16 p.. (2016) Frontiers in Aging Neuroscience, 2016, 8, 16 p. ⟨10.3389/fnagi.2016.00103⟩ |
| ISSN: | 1663-4365 |
| DOI: | 10.3389/fnagi.2016.00103/full |
| Popis: | International audience; Studies suggest that eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and vitamin A are critical to delay aged-related cognitive decline. These nutrients regulate gene expression in the brain by binding to nuclear receptors such as the retinoid X receptors (RXRs) and the retinoic acid receptors (RARs). Moreover, EPA/DHA and retinoids activate notably kinase signaling pathways such as AKT or MAPK, which includes ERK1/2. This suggests that these nutrients may modulate brain function in a similar way. Therefore, we investigated in middle-aged rats the behavioral and molecular effects of supplementations with EPA/DHA and vitamin A alone or combined. 18-month-old rats exhibited reference and working memory deficits in the Morris water maze, associated with a decrease in serum vitamin A and hippocampal EPA/DHA contents. RARα, RXRβ, and RXRγ mRNA expression and CAMKII, AKT, ERK1/2 expression were decreased in the hippocampus of middle-aged rats. A combined EPA/DHA and vitamin A supplementation had a beneficial additive effect on reference memory but not in working memory in middle-aged rats, associated with an alleviation of the age-related decrease in RXRγ, CAMKII, AKT, and ERK1 expression in the hippocampus. This study provides a new combined nutritional strategy to delay brain aging. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|