Caenorhabditis elegans selects distinct crawling and swimming gaits via dopamine and serotonin
| Autor: | Stephen M. Topper, Layla Young, Martin Brauner, Alexander Gottschalk, Abram Axelrod, Leah Kressin, Ashley Crisp, Thomas Maples, Jonathan T. Pierce-Shimomura, Dionicio Siegel, Karen Erbguth, Andrés G. Vidal-Gadea, Erin Elbel |
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| Rok vydání: | 2011 |
| Předmět: |
Serotonin
animal structures Nematode caenorhabditis elegans Dopamine Video Recording Alternate forms Optogenetics Crawling Animals Genetically Modified medicine Animals Caenorhabditis elegans Gait Swimming Multidisciplinary Behavior Animal biology urogenital system Viscosity Dopaminergic Neurons fungi Water Anatomy Biological Sciences biology.organism_classification Biomechanical Phenomena human activities Neuroscience Locomotion Serotonergic Neurons Signal Transduction medicine.drug |
| Zdroj: | Proceedings of the National Academy of Sciences. 108:17504-17509 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1108673108 |
| Popis: | Many animals, including humans, select alternate forms of motion (gaits) to move efficiently in different environments. However, it is unclear whether primitive animals, such as nematodes, also use this strategy. We used a multifaceted approach to study how the nematode Caenorhabditis elegans freely moves into and out of water. We demonstrate that C. elegans uses biogenic amines to switch between distinct crawling and swimming gaits. Dopamine is necessary and sufficient to initiate and maintain crawling after swimming. Serotonin is necessary and sufficient to transition from crawling to swimming and to inhibit a set of crawl-specific behaviors. Further study of locomotory switching in C. elegans and its dependence on biogenic amines may provide insight into how gait transitions are performed in other animals. |
| Databáze: | OpenAIRE |
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