IL-15/IL-15 receptor biology: a guided tour through an expanding universe
| Autor: | Elena Bulanova, Vadim Budagian, Ralf Paus, Silvia Bulfone-Paus |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Interleukin-15
Lymphokine-activated killer cell Receptors Interleukin-15 Endocrinology Diabetes and Metabolism ZAP70 medicine.medical_treatment Immunology Receptors Interleukin-2 Biology Natural killer T cell General Biochemistry Genetics and Molecular Biology Cell biology Autoimmune Diseases Interleukin 21 Cytokine Interleukin 15 Interleukin 12 medicine Immunology and Allergy Animals Humans IL-2 receptor Signal Transduction |
| Zdroj: | Cytokinegrowth factor reviews. 17(4) |
| ISSN: | 1359-6101 |
| Popis: | The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL-15 affects a wider range of target cell populations and utilizes different mechanisms of signaling. Here, we review recent advances in the IL-15-mediated signaling, and in the functional properties on cells besides T lymphocytes and NK cells. These are discussed in the context of their potential clinical and therapeutic relevance. |
| Databáze: | OpenAIRE |
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