Diagnostic Accuracy of Intraocular Tumor Size Measured with MR Imaging in the Prediction of Postlaminar Optic Nerve Invasion and Massive Choroidal Invasion of Retinoblastoma
Autor: | De Jong, Marcus C., van der Meer, Fenna J. S., Goricke, Sophia L., Brisse, Herve J., Galluzzi, Paolo, Maeder, Philippe, Sirin, Selma, De Francesco, Sonia, Sastre-Garau, Xavier, Metz, Klaus A., Cerase, Alfonso, Noij, Daniel P., van der Valk, Paul, Moll, Annette C., Castelijns, Jonas A., de Graaf, Pim |
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Přispěvatelé: | Radiology and nuclear medicine, Cardio-thoracic surgery, Pathology, Ophthalmology, EMGO - Quality of care, CCA - Imaging |
Rok vydání: | 2016 |
Předmět: |
Male
Pathology medicine.medical_specialty Retinal Neoplasms Enucleation Medizin Intraocular Retinoblastoma 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Risk Factors Humans Medicine Neoplasm Invasiveness Radiology Nuclear Medicine and imaging Retrospective Studies medicine.diagnostic_test Receiver operating characteristic business.industry Retinoblastoma Choroid Neoplasms Optic Nerve Neoplasms Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Confidence interval 030221 ophthalmology & optometry Optic nerve Regression Analysis Population study Female business Nuclear medicine Forecasting |
Zdroj: | De Jong, M C, van der Meer, F J S, Goricke, S L, Brisse, H J, Galluzzi, P, Galluzzi, P, Maeder, P, Sirin, S, De Francesco, S, Sastre-Garau, X, Metz, K A, Cerase, A, Noij, D P, van der Valk, P, Moll, A C, Castelijns, J A & de Graaf, P 2016, ' Diagnostic Accuracy of Intraocular Tumor Size Measured with MR Imaging in the Prediction of Postlaminar Optic Nerve Invasion and Massive Choroidal Invasion of Retinoblastoma ', Radiology, vol. 279, no. 3, pp. 817-826 . https://doi.org/10.1148/radiol.2015151213 Radiology, 279(3), 817-826. Radiological Society of North America Inc. |
ISSN: | 1527-1315 0033-8419 |
Popis: | Purpose To assess the correlation of intraocular retinoblastoma tumor size measured with magnetic resonance (MR) imaging in the prediction of histopathologically determined metastatic risk factors (postlaminar optic nerve invasion and massive choroidal invasion). Materials and Methods The ethics committee approved this retrospective multicenter study with a waiver of informed consent. The study population included 370 consecutive patients with retinoblastoma (375 eyes) who underwent baseline MR imaging, followed by primary enucleation from 1993 through 2014. Tumor sizes (maximum diameter and volume) were measured independently by two observers and correlated with histopathologic risk factors. Receiver operating characteristic curves were used to analyze the diagnostic accuracy of tumor size, and areas under the curve were calculated. Logistic regression analysis was performed to evaluate potential confounders. Results Receiver operating characteristic analysis of volume and diameter, respectively, yielded areas under the curve of 0.77 (95% confidence interval [CI]: 0.70, 0.85; P < .0001) and 0.78 (95% CI: 0.71, 0.85; P < .0001) for postlaminar optic nerve invasion (n = 375) and 0.67 (95% CI: 0.57, 0.77; P = .0020) and 0.70 (95% CI: 0.59, 0.80; P = .0004) for massive choroidal tumor invasion (n = 219). For the detection of co-occurring massive choroidal invasion and postlaminar optic nerve invasion (n = 219), volume and diameter showed areas under the curve of 0.81 (95% CI: 0.70, 0.91; P = .0032) and 0.83 (95% CI: 0.73, 0.93; P = .0016), respectively. Conclusion Intraocular tumor size shows a strong association with postlaminar optic nerve invasion and a moderate association with massive choroidal invasion. These findings provide diagnostic accuracy measures at different size cutoff levels, which could potentially be useful in a clinical setting, especially within the scope of the increasing use of eye-salvage treatment strategies. (©) RSNA, 2015 Online supplemental material is available for this article. |
Databáze: | OpenAIRE |
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