Association of SLC15A1 polymorphisms with susceptibility to dyslipidaemia in a Chinese Han population

Autor:	Yao Chen, Chun-Yang Wang, Shi-Fang Peng, Zhi-Rong Tan, Xiao-Ping Chen, Shu Liu
Rok vydání:	2019
Předmět:	Male medicine.medical_specialty Single-nucleotide polymorphism Lower risk Logistic regression Peptide Transporter 1 Polymorphism Single Nucleotide 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Asian People Gene Frequency Internal medicine Genotype medicine Humans SNP Genetic Predisposition to Disease Pharmacology (medical) 030212 general & internal medicine Allele Genotyping Alleles Dyslipidemias Pharmacology business.industry Haplotype nutritional and metabolic diseases Middle Aged Haplotypes Case-Control Studies Female business
Zdroj:	Journal of Clinical Pharmacy and Therapeutics. 44:868-874
ISSN:	1365-2710 0269-4727
DOI:	10.1111/jcpt.13016
Popis:	WHAT IS KNOWN AND OBJECTIVE Dyslipidaemia is an increasingly serious clinical and public health issue. In this study, we aim to explore the association of genetic polymorphisms in solute carrier transporter (SLC) 15A1 with the risk of dyslipidaemia in a Chinese Han population. METHODS Three single nucleotide polymorphisms (SNPs) in SLC15A1 (rs2297322, rs4646234 and rs1289389) were selected using bioinformatics in a Chinese Han population with 530 participants. Genotyping was conducted with Sequenom MassARRAY. A logistic regression model was used for the analysis of the association between genotypes and dyslipidaemia. SHEsis software was applied to the haplotype analysis. RESULTS AND DISCUSSION The SLC15A1 rs2297322 TT genotype was associated with a lower risk of hypertriglyceridaemia compared with the CC genotype (OR = 0.44, 95% CI = 0.21-0.93, P = .032). The carriers of the SLC15A1 rs1289389 T allele were found to be significantly associated with a lower risk of hypertriglyceridaemia compared with the C allele (OR = 0.54, 95% CI = 0.33-0.88, P = .013). In the recessive model, the carriers of the SLC15A1 rs4646234 CC genotype showed a significantly reduced risk of hypercholesterolaemia (OR = 2.29, 95% CI = 1.23-4.28, P = .009). Haplotype analysis showed that the CTC haplotype composed of SLC15A1 rs2297322, rs4646234 and rs1289389 was associated with a lower risk of hypertriglyceridaemia (OR = 1.58, 95% CI = 1.12-2.24, P = .009), whereas the TTC haplotype was associated with a significantly reduced risk of hypertriglyceridaemia (OR = 0.63, 95% CI = 0.40-0.99, P = .045). WHAT IS NEW AND CONCLUSION SLC15A1 rs2297322 and rs1289389 polymorphisms were associated with alterations in the risk of dyslipidaemia in a Chinese Han population.
Databáze:	OpenAIRE
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