Synthesis of N-aryl hydrazides by copper-catalyzed coupling of hydrazides with aryl iodides
| Autor: | Artis Klapars, Stephen L. Buchwald, Martina Wolter |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
inorganic chemicals
organic chemicals Aryl Organic Chemistry Hydrazine Regioselectivity chemistry.chemical_element Biochemistry Medicinal chemistry Copper Catalysis chemistry.chemical_compound Hydrazines chemistry Copper catalyzed Benzene Derivatives Organic chemistry Indicators and Reagents Physical and Theoretical Chemistry Hydrocarbons Iodinated Benzoic hydrazide |
| Zdroj: | Organic letters. 3(23) |
| ISSN: | 1523-7060 |
| Popis: | [reaction--see text] A convenient method for intermolecular N-arylation of hydrazides with substituted aryl iodides in the presence of a copper catalyst and Cs(2)CO(3) is reported. The C-N coupling of N-Boc hydrazine with para- and meta-substituted aryl iodides afforded the N-arylated products A, regioselectively. A reversal in regioselectivity is observed for the arylation of benzoic hydrazide with ortho-substituted aryl iodides, providing the N'-arylated products B. |
| Databáze: | OpenAIRE |
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