Stent-protected angioplasty in asymptomatic carotid artery stenosis vs. endarterectomy: SPACE2 - a three-arm randomised-controlled clinical trial
| Autor: | Tilman Reiff, Gustav Fraedrich, Harald Mudra, Hans-Henning Eckstein, Olav Jansen, Robert Stingele, Werner Hacke, Peter A. Ringleb, Ulrich Mansmann |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Quality Control medicine.medical_specialty Endpoint Determination medicine.medical_treatment Carotid endarterectomy Asymptomatic Risk Factors Internal medicine Angioplasty Carotid artery disease medicine Humans Carotid Stenosis cardiovascular diseases Stroke Aged Endarterectomy Aged 80 and over Endarterectomy Carotid business.industry Middle Aged medicine.disease Surgery Stenosis Neurology Sample Size Cardiology Female Stents Carotid stenting medicine.symptom business |
| Popis: | Moderate to severe (≥70%) asymptomatic stenosis of the extracranial carotid artery leads to an increased rate of stroke of approximately 11% in 5 years. Patients with asymptomatic carotid stenosis, however, are also at a higher risk of nonstroke vascular events. The estimated annual risks of such events in patients with asymptomatic stenosis are 7% for a coronary ischaemic event and 4–7% for overall mortality. The superiority of carotid endarterectomy compared with medical treatment in symptomatic carotid disease is established, provided that the surgical procedure can be performed with a perioperative morbidity and mortality of |
| Databáze: | OpenAIRE |
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