Control of Social Withdrawal of Mice Deficient for the Autism Gene Magel2 by Restoration of Vasopressin-Oxytocin Dialogue in Septum
| Autor: | Yann Dromard, Csaba Tomboli, Maurice Manning, Amélie M. Borie, Djodi Dufner, Freddy Jeanneteau, Gilles Guillon, Emi Pollozi, Damien Huzard, Michel G. Desarménien, Alexandra Olma, Pascal Colson, Françoise Muscatelli |
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| Přispěvatelé: | Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Department of Chemistry, University of Toledo, University of Toledo, Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université] (INMED - INSERM U1249), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Vasopressin business.industry [SDV]Life Sciences [q-bio] Novelty Disease Optogenetics medicine.disease Pathophysiology 03 medical and health sciences 0302 clinical medicine Oxytocin Knockout mouse Medicine Autism business Neuroscience 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists 030304 developmental biology medicine.drug |
| Popis: | SummaryIntellectual and social disabilities are common comorbidities in adolescents and adults with Magel2 gene deficiency characterizing the Prader-Willi and Schaaf-Yang neurodevelopmental syndromes. The cellular and molecular mechanisms underlying the risk for autism in these syndromes are unexplored. Here we used Magel2 knockout mice combined with optogenetic/pharmacological tools to characterize disease modifications in the social brain network. We find that the degree of social novelty moderates a dialogue between vasopressin and oxytocin in the lateral septum, a region organizing sequential content of sensory experiences. Social withdrawal of mice lacking Magel2 is alleviated by restoration of dialogue-lead by vasopressin. This preclinical study identifies the collective actions of vasopressin and oxytocin in the lateral septum as a key factor in the pathophysiology. |
| Databáze: | OpenAIRE |
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