Urinary epidermal and insulin-like growth factor excretion in autistic children
| Autor: | B. Bakkaloglu, F Oktem, N Yordam, B Pehlivanturk, C Ozbesler, F Unal, H Oguz, Banu Anlar, M Haliloglu, Bahar Gökler |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Urinary system medicine.medical_treatment Provocation test Excretion Insulin-like growth factor Epidermal growth factor Internal medicine medicine Humans Autistic Disorder Insulin-Like Growth Factor I Epidermal Growth Factor business.industry Growth factor General Medicine medicine.disease Developmental disorder Endocrinology Case-Control Studies Child Preschool Pediatrics Perinatology and Child Health Autism Female Neurology (clinical) business |
| Zdroj: | Neuropediatrics. 38(3) |
| ISSN: | 0174-304X |
| Popis: | Growth factors have been implicated in the pathogenesis of autism. We have investigated daily urinary excretion of insulin-like growth factor-1 (IGF-1), epidermal growth factor, and insulin-like growth factor binding protein-3 in autistic children (n=34, age 2-5 years) and age-matched control children (n=29). The mean urinary IGF-1 level was lower in the autism group than the control group (p=0.03). Height was normal. These findings suggest altered IGF-1 metabolism in young autistic children. The cause-effect relationship should be examined by longitudinal studies and insulin-like growth factor provocation tests. |
| Databáze: | OpenAIRE |
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