Acyclovir Induced Coma in the Intensive Care Unit
| Autor: | C. K. Reiss, Govind R. Rajan, J. P. Cobb |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Critical Care Critical Illness Multiple Organ Failure medicine.medical_treatment Acyclovir Administration Oral 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine Antiviral Agents 030226 pharmacology & pharmacy Enteral administration law.invention 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Renal Dialysis law medicine Humans Coma Aged Cerebrospinal Fluid Herpes Labialis Mechanical ventilation business.industry Brain Electroencephalography Respiration Artificial Intensive care unit Induced coma Anesthesiology and Pain Medicine Anesthesia Etiology medicine.symptom Tomography X-Ray Computed business |
| Zdroj: | Anaesthesia and Intensive Care. 28:305-307 |
| ISSN: | 1448-0271 0310-057X |
| DOI: | 10.1177/0310057x0002800309 |
| Popis: | A 73-year-old man with multiorgan failure requiring mechanical ventilation and haemodialysis developed herpes labialis infection during his stay in the ICU. This was treated with enteral acyclovir. He developed persistent neurologic impairment soon after acyclovir administration, which, over the course of seven days, progressed to coma, the aetiology of which was unclear. The computed tomograph (CT) of the brain and the cerebrospinal fluid (CSF) examination was normal. The electroencephalogram (EEG) showed generalized slowing. The possibility of acyclovir neurotoxicity was considered and the drug was discontinued. Haemodialysis was instituted and the patient made a complete neurological recovery. We believe that this is the first reported case of coma due to enteral acyclovir. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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