Innovative in silico approaches to address avian flu using grid technology
| Autor: | Ana Lucia da Costa, Doman Kim, Hong Quang Nguyen, Paul de Vlieger, Vincent Breton, Young-Min Kim, Nam Hai Truong, Yin-Ta Wu, Lydia Maigne, Romain Reuillon, David Sarramia |
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| Rok vydání: | 2009 |
| Předmět: |
Microbiology (medical)
Technology In silico Early detection Biology 010402 general chemistry computer.software_genre medicine.disease_cause 01 natural sciences Birds 03 medical and health sciences Globalization 0302 clinical medicine Zoonoses medicine Animals Computer Simulation 030212 general & internal medicine Simulation Pharmacology Virtual screening Molecular Epidemiology Influenza A Virus H5N1 Subtype General Medicine Grid Data science Influenza A virus subtype H5N1 0104 chemical sciences 3. Good health Grid computing Influenza in Birds Mutation Molecular Medicine computer Sentinel Surveillance |
| Zdroj: | Infectious disorders drug targets. 9(3) |
| ISSN: | 2212-3989 |
| Popis: | The recent years have seen the emergence of diseases which have spread very quickly all around the world either through human travels like SARS or animal migration like avian flu. Among the biggest challenges raised by infectious emerging diseases, one is related to the constant mutation of the viruses which turns them into continuously moving targets for drug and vaccine discovery. Another challenge is related to the early detection and surveillance of the diseases as new cases can appear just anywhere due to the globalization of exchanges and the circulation of people and animals around the earth, as recently demonstrated by the avian flu epidemics. For 3 years now, a collaboration of teams in Europe and Asia has been exploring some innovative in silico approaches to better tackle avian flu taking advantage of the very large computing resources available on international grid infrastructures. Grids were used to study the impact of mutations on the effectiveness of existing drugs against H5N1 and to find potentially new leads active on mutated strains. Grids allow also the integration of distributed data in a completely secured way. The paper proposes new approaches for the integration of existing data sources towards a global surveillance network for molecular epidemiology and in silico drug discovery. |
| Databáze: | OpenAIRE |
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