Anti-inflammatory properties of some novel thiazolo[4,5-b]pyridin-2-ones
| Autor: | Olexandra Komarytsya, Ihor Nektegaev, Vasyl S. Matiychuk, Iryna Myrko, T. I. Chaban, I. G. Chaban, V. V. Ogurtsov |
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| Rok vydání: | 2020 |
| Předmět: |
thiazolo[4
5-b]pyridines 010405 organic chemistry medicine.drug_class Chemistry Pharmaceutical Science Pharmacy Pharmacology organic synthesis 01 natural sciences Anti-inflammatory 0104 chemical sciences 010404 medicinal & biomolecular chemistry anti-inflammatory activity organic synthesis thiazolo[4 5-b]pyridines medicine Pharmacology (medical) anti-inflammatory activity |
| Zdroj: | Pharmacia 67(3): 121-127 |
| ISSN: | 2603-557X 0428-0296 |
| Popis: | Synthesis of novel N3 and C5 substituted thiazolo[4,5-b]pyridin-2-ones was carried out on the basis of [3+3]-cyclocodensation, acylation and alkylation reactions. The structures of the obtained compounds were confirmed by 1H NMR spectroscopy, and elemental analysis. The anti-inflammatory action of novel thiazolo[4,5-b]pyridine-2-one derivatives was evaluated in vivo employing the carrageenan-induced rat paw edema method. When compared with Ibuprofen, some our compounds were found to be more potent. Graphical abstract |
| Databáze: | OpenAIRE |
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