Development of 2,4-diaminopyrimidine derivatives as novel SNSR4 antagonists
| Autor: | Joanne Butterworth, Malken Bayrakdarian, Vijayaratnam Santhakumar, Yun-Jin Hu, Tomaszewski Miroslaw |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pyrimidine
Sensory Receptor Cells Stereochemistry Chemistry medicine.drug_class Organic Chemistry Clinical Biochemistry Pharmaceutical Science Carboxamide Receptors Cell Surface Biochemistry chemistry.chemical_compound Inhibitory Concentration 50 Diaminopyrimidine Pyrimidines Drug Discovery medicine Molecular Medicine Structure–activity relationship Inhibitory concentration 50 heterocyclic compounds Molecular Biology |
| Zdroj: | Bioorganicmedicinal chemistry letters. 21(7) |
| ISSN: | 1464-3405 |
| Popis: | 2,4-Diaminopyrimidines derivatives were developed as a novel class of SNSR4 antagonists. Structure activity relationship of the diamino pyrimidine core was explored and a tool compound suitable for target validation was identified. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect