AMPed-up adolescents: the role of age in the abuse of amphetamines and its consequences on cognition and prefrontal cortex development
| Autor: | Lauren K. Carrica, Sara R. Westbrook, Joshua M. Gulley, Asia Banks |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Clinical Biochemistry Amphetamine-Related Disorders Prefrontal Cortex Toxicology Biochemistry Article Developmental psychology Methamphetamine 03 medical and health sciences Behavioral Neuroscience Young Adult 0302 clinical medicine Cognition Sex Factors Epidemiology medicine Animals Humans Young adult Amphetamine Prefrontal cortex Child Biological Psychiatry Pharmacology Age differences Age Factors Brain Adolescent Development 030227 psychiatry Adolescent Behavior Central Nervous System Stimulants Female Animal studies Psychology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Pharmacol Biochem Behav |
| DOI: | 10.31219/osf.io/t58qe |
| Popis: | Adolescent use of amphetamine and its closely related, methylated version methamphetamine, is alarmingly high in those who use drugs for nonmedical purposes. This raises serious concerns about the potential for this drug use to have a long-lasting, detrimental impact on the normal development of the brain and behavior that is ongoing during adolescence. In this review, we explore recent findings from both human and laboratory animal studies that investigate the consequences of amphetamine and methamphetamine exposure during this stage of life. We highlight studies that assess sex differences in adolescence, as well as those that are designed specifically to address the potential unique effects of adolescent exposure by including groups at other life stages (typically young adulthood). We consider epidemiological studies on age and sex as vulnerability factors for developing problems with the use of amphetamines, as well as human and animal laboratory studies that tap into age differences in use, its short-term effects on behavior, and the long-lasting consequences of this exposure on cognition. We also focus on studies of drug effects in the prefrontal cortex, which is known to be critically important for cognition and is among the later maturing brain regions. Finally, we discuss important issues that should be addressed in future studies so that the field can further our understanding of the mechanisms underlying adolescent use of amphetamines and its outcomes on the developing brain and behavior. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|