Contribution of chemotherapy mobilization to disease control in multiple myeloma treated with autologous hematopoietic cell transplantation
| Autor: | Reinhold Munker, Heather Landau, Matt Kalaycio, Siddhartha Ganguly, R. T. Kamble, Mohamed A. Kharfan-Dabaja, William A. Wood, Aparna Krishnan, Ayman Saad, Miguel Pérez, Natalie S. Callander, Robert F. Cornell, Angela Dispenzieri, Harry C. Schouten, Cesar O. Freytes, Parameswaran Hari, Richard F. Olsson, Anita D'Souza, Shaji Kumar, Morie A. Gertz, Manish Sharma, Jason Tay, Dan T. Vogl, KC Anderson, L. B. To, Mei-Jie Zhang, Bipin N. Savani, John L. Wagner, Angelo Maiolino, David I. Marks, Mehdi Hamadani, Alfred L. Garfall, Cindy Lee, D. H. Vesole, John Gibson, Luciano J. Costa, Tomer M Mark, Jiaxing Huang, Baldeep Wirk, Tulio E. Rodriguez, Robert Peter Gale, Sachiko Seo, Hillard M. Lazarus, Edward A. Stadtmauer, Gary J. Schiller, Emma C. Scott, Robert A. Kyle, Jeffrey Schriber, Taiga Nishihori, Muthalagu Ramanathan, Christopher Bredeson, Geoffrey L. Uy |
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| Přispěvatelé: | MUMC+: MA Hematologie (9), Interne Geneeskunde, RS: GROW - Oncology, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Platelet Engraftment Adolescent medicine.medical_treatment Clinical Sciences Oncology and Carcinogenesis Immunology Hematopoietic stem cell transplantation Regenerative Medicine Gastroenterology Disease-Free Survival Article Leukocyte Count Rare Diseases Stem Cell Research - Nonembryonic - Human Clinical Research Internal medicine Medicine Humans Prospective Studies Autografts Hematopoietic Stem Cell Mobilization Multiple myeloma Cancer Aged Chemotherapy Transplantation Neutrophil Engraftment Hematology business.industry Platelet Count Hematopoietic Stem Cell Transplantation Recovery of Function Middle Aged medicine.disease Stem Cell Research 3. Good health Surgery Survival Rate Female business Multiple Myeloma |
| Zdroj: | Bone marrow transplantation Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid Bone Marrow Transplantation, 50(12). Nature Publishing Group Bone marrow transplantation, vol 50, iss 12 |
| ISSN: | 1476-5365 0268-3369 |
| Popis: | In patients with multiple myeloma (MM) undergoing autologous hematopoietic cell transplantation (auto-HCT), peripheral blood progenitor cells (PBPCs) may be collected following mobilization with growth factor alone (GF) or cytotoxic chemotherapy plus GF ( (CC+GF). It is uncertain whether the method of mobilization affects post-transplant outcomes. We compared these mobilization strategies in a retrospective analysis of 968 patients with MM from the Center for International Blood and Marrow Transplant Research database who received an auto-HCT in the US and Canada between 2007 and 2012. The kinetics of neutrophil engraftment (≥ 0.5 × 109/L) was similar between groups (13 vs. 13 days, P=0.69) while platelet engraftment (≥ 20 × 109/L) was slightly faster with CC+GF (19 vs. 18 days, P=0.006). Adjusted 3-years PFS was 43% (95% C.I. 38–48) in GF and 40% (95% C.I. 35–45) in CC+GF, P=0.33. Adjusted 3-years OS was 82% (95% C.I. 78–86) vs. 80% (95% C.I. 75–84), P=0.43 and adjusted 5-year OS was 62% (95C.I. 54–68) vs. 60% (95% C.I. 52–67), P=0.76, for GF and CC+GF respectively. We conclude that MM patients undergoing auto-HCT have similar outcomes irrespective of the method of mobilization and found no evidence that the addition of chemotherapy to mobilization contributes to disease control. |
| Databáze: | OpenAIRE |
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