Neonatal Group B Streptococcal Meningitis: Predictors for Poor Neurologic Outcome at 18 Months
| Autor: | Petja Fister, Jerneja Peček, Samo Jeverica, Zvonka Rener Primec, Darja Paro-Panjan |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Serotype medicine.medical_specialty Disease medicine.disease_cause Group B Meningitis Bacterial Epilepsy Disease severity Streptococcal Infections Internal medicine medicine Humans Retrospective Studies business.industry Streptococcus Group B streptococcal meningitis Infant Newborn Infant medicine.disease Anti-Bacterial Agents Treatment Outcome Pediatrics Perinatology and Child Health Female Neurology (clinical) business Meningitis |
| Zdroj: | Journal of Child Neurology. 37:64-72 |
| ISSN: | 1708-8283 0883-0738 |
| DOI: | 10.1177/08830738211053128 |
| Popis: | Aim To find early predictors for poor neurodevelopmental outcome after neonatal group B streptococcal meningitis. Methods We retrospectively analyzed clinical characteristics of 23 patients with neonatal group B streptococcal meningitis and their neurodevelopmental outcome at 18 months. Available group B Streptococcus strains were serotyped and their genomes characterized. Results We found several differences between patients with early- (n = 5) and late-onset (n = 18) disease. Nine children had neurologic abnormalities at 18 months and 4 had epilepsy, all of them after late-onset disease. Most important risk factors for poor outcome were impaired consciousness at admission, hemodynamic instability, seizures, or abnormal electroencephalogram during the acute illness and abnormal neurologic and ophthalmologic examination at the end of treatment, whereas abnormalities in laboratory and imaging studies were not predictive. Hypervirulent serotype III, multilocus sequence type 17 group B Streptococcus was the predominant pathogen. Conclusions Neurodevelopmental impairment after neonatal group B streptococcal meningitis is likelier in those with clinical and neurophysiological features indicating worse disease severity. |
| Databáze: | OpenAIRE |
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