Correlation between urinary and serum NT-proBNP in acute bronchiolitis: A pilot study
| Autor: | Moises Rodríguez‐González, Ana Castellano‐Martínez, Ana Estalella‐Mendoza, Patricia Rodríguez‐Campoy, Lorena Estepa‐Pedregosa, María Mercedes Calero‐Ruiz, Ana Sáez‐Benito Godino, Jose Carlos Flores‐González |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Pulmonary and Respiratory Medicine
acute bronchiolitis pneumonia [infections] biomarkers Infant Pilot Projects Peptide Fragments TB pulmonary hypertension Natriuretic Peptide Brain Pediatrics Perinatology and Child Health myocardial strain Humans Bronchiolitis natriuretic peptides urinary NT-proBNP viral |
| Zdroj: | Pediatric pulmonologyREFERENCES. |
| ISSN: | 1099-0496 |
| Popis: | Background and aims: We aimed to analyze the correlation of urinary with serum NT-proBNP concentrations in acute bronchiolitis and its association with the severity of the disease. Material and Methods: A pilot observational study conducted between 1st October and 31st March 2022, including acute bronchiolitis cases who attended our institution. Serum and urinary NT-proBNP concentrations were determined using the Alere NT-proBNP assay in time-matched urine and blood samples. We explored the linear relationship between both concentrations and compared clinical outcomes indicative of severe acute bronchiolitis between groups of raised and normal urinary NT-proBNP. Results: 17 infants (median age 68 (36-91) days) with 36 time-matched samples were included. The urinary and serum concentrations of NT-proBNP were significantly correlated with (r=0.867 & R-squared coefficient=0.751; pConclusion: The measurement of urinary NT-proBNP concentrations could be a reliable surrogate for serum NT-proBNP levels highlighting the potential value of the urinary NT-proBNP as a non-invasive tool to assess severity in acute bronchiolitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text