Constrained bisantrene derivatives as G-quadruplex binders
| Autor: | Valeria Pavan, Matteo Scalabrin, Giuseppe Zagotto, Daniele Fabris, Giovanni Ribaudo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Bisantrene
Anthracene DNA Fluorimetry G-quadruplex Mass spectrometry Organic Chemistry 01 natural sciences Fluorescence spectroscopy lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry heterocyclic compounds 010405 organic chemistry Combinatorial chemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Duplex (building) Stoichiometry |
| Zdroj: | ARKIVOC, Vol 2016, Iss 3, Pp 145-160 (2016) |
| ISSN: | 1551-7012 1551-7004 |
| Popis: | We here report the synthesis and evaluation of constrained derivatives of a bisantrene isomer known to bind DNA when structured in G-quadruplex. Enhanced high-resolution mass spectrometry was used to evaluate the binding efficiency and stoichiometry of the compounds towards G-quadruplex DNA using a duplex sequence for comparison. Fluorimetric DNA binding studies supported and confirmed these preliminary observations. One of the newly synthesized compounds showed a high tendency and specificity to bind the structured G-quadruplex DNA. |
| Databáze: | OpenAIRE |
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