Grey matter volume alterations in CADASIL: a voxel-based morphometry study
| Autor: | ROSSI ESPAGNET, MARIA CAMILLA, Mcr, Espagnet, Maria Camilla Rossi Espagnet, Romano, Andrea, Carducci, Filippo, Luigi Fausto Calabria, Martina, Fiorillo, Orzi, Francesco, Bozzao, Alessandro |
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| Jazyk: | angličtina |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Neurology Original Clinical Neurology Grey matter 030218 nuclear medicine & medical imaging White matter Lesion 03 medical and health sciences 0302 clinical medicine Atrophy dartel vbm dementia cadasil medicine Humans Gray Matter CADASIL business.industry Microangiopathy General Medicine Voxel-based morphometry Middle Aged medicine.disease Magnetic Resonance Imaging Temporal Lobe 3. Good health medicine.anatomical_structure Anesthesiology and Pain Medicine Case-Control Studies Regression Analysis Female Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Headache and Pain |
| ISSN: | 1129-2369 |
| DOI: | 10.1007/s10194-012-0418-9 |
| Popis: | CADASIL is a hereditary disease characterized by cerebral subcortical microangiopathy leading to early onset cerebral strokes and progressive severe cognitive impairment. Until now, only few studies have investigated the extent and localization of grey matter (GM) involvement. The purpose of our study was to evaluate GM volume alterations in CADASIL patients compared to healthy subjects. We also looked for correlations between global and regional white matter (WM) lesion load and GM volume alterations. 14 genetically proved CADASIL patients and 12 healthy subjects were enrolled in our study. Brain MRI (1.5 T) was acquired in all subjects. Optimized-voxel based morphometry method was applied for the comparison of brain volumes between CADASIL patients and controls. Global and lobar WM lesion loads were calculated for each patient and used as covariate-of-interest for regression analyses with SPM-8. Compared to controls, patients showed GM volume reductions in bilateral temporal lobes (p |
| Databáze: | OpenAIRE |
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