In Vivo Testing of Extracorporeal Membrane Ventilators: iLA-Activve Versus Prototype I-Lung
| Autor: | Esther Novosel, Georg Matheis, Beate Brock, Peter I. Lelkes, Johan von Grönheim, Brigitte Vollmar, Anne Herbst, Philipp Warnke, Sabine Kischkel, Andreas Podbielski, Jan P. Roesner, Joerg Schneider, Marc-Jonas Epping, Stefan Bergt |
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| Rok vydání: | 2017 |
| Předmět: |
Lung Diseases
Swine medicine.medical_treatment Biomedical Engineering Biophysics Bioengineering 030204 cardiovascular system & hematology Decarboxylation Extracorporeal Biomaterials 03 medical and health sciences 0302 clinical medicine Extracorporeal Membrane Oxygenation In vivo Jugular vein Extracorporeal membrane oxygenation medicine Animals Respiratory system Lung Ventilators Mechanical business.industry 030208 emergency & critical care medicine General Medicine Carbon Dioxide Hypoventilation Oxygen medicine.anatomical_structure Anesthesia Models Animal medicine.symptom business Hypercapnia |
| Zdroj: | ASAIO journal (American Society for Artificial Internal Organs : 1992). 63(2) |
| ISSN: | 1538-943X |
| Popis: | A side-by-side comparison of the decarboxylation efficacy of two pump-driven venovenous extracorporeal lung assist devices, i.e., a first prototype of the new miniaturized ambulatory extracorporeal membrane ventilator, I-lung versus the commercial system iLA-activve for more than a period of 72 hours in a large animal model. Fifteen German Landrace pigs were anesthetized and underwent mechanical hypoventilation to induce severe hypercapnia. Decarboxylation was accomplished by either the I-lung or the iLA-activve via a double lumen catheter in the jugular vein. Sham-operated pigs were not connected to extracorporeal devices. Cardiovascular, respiratory, and metabolic parameters were continuously monitored, combined with periodic arterial blood sampling for subsequent clinical blood diagnostics, such as gas exchange, hemolysis, coagulation parameters, and cytokine profiles. At the termination of the studies, lung tissue was harvested and examined histologically for pulmonary morphology and leukocyte tissue infiltration. Both extracorporeal devices showed high and comparable efficacy with respect to carbon dioxide elimination for more than 72 hours and were not associated with either bleeding events or clotting disorders. Pigs of both groups showed cardiovascular and hemodynamic stability without marked differences to sham-operated animals. Groups also did not differ in terms of inflammatory and metabolic parameters. We established a preclinical in vivo porcine model for comparative long-term testing of I-lung and iLA-activve. The I-lung prototype proved to be safe and feasible, providing adequate decarboxylation without any adverse events. Once translated into the clinical treatment, the new miniaturized and transportable I-lung device might represent a promising tool for treating awake and mobilized patients with decompensated pulmonary disorders. |
| Databáze: | OpenAIRE |
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