Corticotropin-releasing hormone administration increases alpha-melanocyte-stimulating hormone levels in the inferior petrosal sinuses in a subset of patients with Cushing's disease
| Autor: | Paolo Marzullo, Françoise Boudouresque, Francesca S. Tripodi, Antonella Di Sarno, Charles Oliver, Bartolomeo Merola, Annamaria Colao, G. Cerbone, Gaetano Lombardi, Diego Ferone |
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| Přispěvatelé: | Colao, Annamaria, Merola, Bartolomeo, DI SARNO, Antonella, D., Ferone, P., Marzullo, G., Cerbone, F. S., Tripodi, F., Boudouresque, C., Oliver, Lombardi, Gaetano |
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Adolescent Corticotropin-Releasing Hormone Endocrinology Diabetes and Metabolism Prolactin blood alpha-melanocyte-stimulating hormone inferior petrosal sinuse Petrosal Sinus Sampling chemistry.chemical_compound Corticotropin-releasing hormone Endocrinology Adrenocorticotropic Hormone Internal medicine medicine Humans Crh test Cushing Syndrome business.industry beta-Endorphin Cushing's disease Middle Aged medicine.disease alpha-Melanocyte-stimulating hormone Prolactin chemistry alpha-MSH Female business hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Hormone research. 46(1) |
| ISSN: | 0301-0163 |
| Popis: | The effect of corticotropin (ACTH)-releasing hormone (CRH) administration on alpha-melanocyte-stimulating hormone (alpha-MSH), ACTH and beta-endorphin (beta-EPH) was evaluated in the inferior petrosal sinuses and in the periphery of 30 patients affected with Cushing's disease subjected to simultaneous and bilateral inferior petrosal sinus sampling for diagnostic purposes. Baseline PRL levels, sensitivity to dexamethasone and surgery outcome were compared to alpha-MSH response. CRH bolus did not modify alpha-MSH concentrations either in the inferior petrosal sinuses or in the periphery in the 30 patients considered as a whole. In 7 of 30 patients, however, a greater than 50% increase over baseline alpha-MSH levels (from 50 to 115.5%) was recorded in the inferior petrosal sinus ipsilateral to the adenoma (from 42.9 +/- 1.7 to 76.4 +/- 4.6 ng/l; p < 0.001), whereas no change was found in the contralateral inferior petrosal sinus or in the periphery. Conversely, as expected, ACTH and beta-ELI significantly increased in all the patients after CRH both in the inferior petrosal sinuses and in the periphery (particularly in the inferior petrosal sinus ipsilateral to the adenoma). No difference in sensitivity to dexamethasone (urinary cortisol percent decrease: 66.4 +/- 4.9 vs. 67.8 +/- 3.4) and surgery outcome (chi 2 test: p = 0.7) was found between patients with alpha-MSH response to CRH and patients without such a response. By contrast, baseline PRL levels, although being normal in both groups, were significantly higher in patients with alpha-MSH response to CRH (18.1 +/- 1.6 vs. 10.1 +/- 0.7 micrograms/l; p < 0.001). In conclusion, the results of the present study suggest that in a subset of patients with Cushing's disease (23.3% of our series) alpha-MSH may be released after the administration of CRH together with ACTH and beta-EPH by adenomatous corticotrophs. In this subset of patients, PRL levels may be in the upper normal range. |
| Databáze: | OpenAIRE |
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