Human dietary exposure to chemicals in sub-Saharan Africa: safety assessment through a total diet study
| Autor: | Lionel Lopes-Pereira, Eric Jazet, Jean Kamanzi, Michael Sulyok, Sylvestre Dansou, Abdoulaye Zié Koné, Bruno Le Bizec, Philippe Verger, Samson B. Adebayo, Zima J. Diallo, Sara Eyangoh, Marie Madeleine Gimou, Sètondji Epiphane Hossou, Luc Ingenbleek, Julius Ogungbangbe, Philippe Marchand, Anaclet D. Dzossa, Jean-Charles Leblanc, Thierry Guérin, Blaise Ouattara, Abimbola Adegboye, Renwei Hu, Renata Clarke, Rudolf Krska, Petru Jitaru, Markus Lipp, Caroline Merten |
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| Přispěvatelé: | Centre Pasteur du Cameroun, Réseau International des Instituts Pasteur (RIIP), Laboratoire d'étude des Résidus et Contaminants dans les Aliments (LABERCA), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), World Health Organisation (WHO), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), National Agency for Food and Drug Administration and Control [Nigéria] (NAFDAC), Ministère de la Santé Publique [Niger], Agence Béninoise de Sécurité Sanitaire des Aliments [Cotonou, Bénin] (ABSSA), Agence Nationale pour la Sécurité Sanitaire des Aliments [Bamako, Mali] (ANSSA), Ministry of Health, Institut National de Recherche en Santé Publique, Mali, National Institute for Statistics, National Bureau of Statistics, Institut National de la Statistique et de l'Analyse Economique, ANSSA - Agence Nationale pour la Sécurité Sanitaire des Aliments, Laboratoire de sécurité des aliments de Maisons-Alfort (LSAl), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), INOVALYS, University of Natural Resources and Life Sciences (BOKU), FAO Regional Office for Africa [Accra] (FAO), Food and Agriculture Organization of the United Nations [Rome, Italie] (FAO), Standards and Trade Development Facility |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Ochratoxin A
Aflatoxin Health (social science) MESH: Dietary Exposure polycyclic aromatic hydrocarbons Medicine (miscellaneous) 010501 environmental sciences Mali 01 natural sciences Dietary Exposure chemistry.chemical_compound 0302 clinical medicine Benin 030212 general & internal medicine Cameroon 2. Zero hunger Health Policy 1. No poverty 3. Good health MESH: Environmental Pollutants Chlorpyrifos [SDV.TOX]Life Sciences [q-bio]/Toxicology Environmental Pollutants [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology Hazard Analysis and Critical Control Points medicine.medical_specialty Nigeria [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain Health(social science) 03 medical and health sciences SDG 3 - Good Health and Well-being MESH: Diet Cameroun Environmental health medicine Humans MESH: Hazard Analysis and Critical Control Points SDG 2 - Zero Hunger Carcinogen 0105 earth and related environmental sciences business.industry Public health Public Health Environmental and Occupational Health Pesticide Diet Citrinin Smoked fish chemistry business Afrique Sub-saharienne [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Food Analysis |
| Zdroj: | The Lancet Planetary Health The Lancet Planetary Health, 2020, 4 (7), pp.e292-e300. ⟨10.1016/S2542-5196(20)30104-2⟩ Ingenbleek, L, Verger, P, Gimou, M M, Adegboye, A, Adebayo, S B, Hossou, S E, Koné, A Z, Jazet, E, Dzossa, A D, Ogungbangbe, J, Dansou, S, Diallo, Z J, Jitaru, P, Guérin, T, Lopes-Pereira, L, Hu, R, Sulyok, M, Krska, R, Marchand, P, Le Bizec, B, Eyangoh, S, Kamanzi, J, Ouattara, B, Merten, C, Lipp, M, Clarke, R & Leblanc, J C 2020, ' Human dietary exposure to chemicals in sub-Saharan Africa: safety assessment through a total diet study ', The Lancet Planetary Health, vol. 4, no. 7, pp. e292-e300 . https://doi.org/10.1016/S2542-5196(20)30104-2 |
| ISSN: | 2542-5196 |
| Popis: | Summary Background Human dietary exposure to chemicals can result in a wide range of adverse health effects. Some substances might cause non-communicable diseases, including cancer and coronary heart diseases, and could be nephrotoxic. Food is the main human exposure route for many chemicals. We aimed to assess human dietary exposure to a wide range of food chemicals. Methods We did a total diet study in Benin, Cameroon, Mali, and Nigeria. We assessed 4020 representative samples of foods, prepared as consumed, which covered more than 90% of the diet of 7291 households from eight study centres. By combining representative dietary surveys of countries with findings for concentrations of 872 chemicals in foods, we characterised human dietary exposure. Findings Exposure to lead could result in increases in adult blood pressure up to 2·0 mm Hg, whereas children might lose 8·8–13·3 IQ points (95th percentile in Kano, Nigeria). Morbidity factors caused by coexposure to aflatoxin B1 and hepatitis B virus, and sterigmatocystin and fumonisins, suggest several thousands of additional liver cancer cases per year, and a substantial contribution to the burden of chronic malnutrition in childhood. Exposure to 13 polycyclic aromatic hydrocarbons from consumption of smoked fish and edible oils exceeded levels associated with possible carcinogenicity and genotoxicity health concerns in all study centres. Exposure to aluminium, ochratoxin A, and citrinin indicated a public health concern about nephropathies. From 470 pesticides tested across the four countries, only high concentrations of chlorpyrifos in smoked fish (unauthorised practice identified in Mali) could pose a human health risk. Interpretation Risks characterised by this total diet study underscore specific priorities in terms of food safety management in sub-Saharan Africa. Similar investigations specifically targeting children are crucially needed. Funding Standards and Trade Development Facility. |
| Databáze: | OpenAIRE |
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