Polymer-amino-functionalized silica composites for the sustained-release multiparticulate system
| Autor: | Agnieszka Kierys, Marta Grochowicz, Andrzej Sienkiewicz, Regina Kasperek |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Diclofenac Nitrogen Polymers Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Amino functionalized Biomaterials chemistry.chemical_compound Ammonia X-Ray Diffraction medicine Amines chemistry.chemical_classification Calorimetry Differential Scanning Silica gel Temperature Sorption Polymer Diclofenac Sodium 021001 nanoscience & nanotechnology Silicon Dioxide Enteric coating 0104 chemical sciences Drug Liberation Kinetics chemistry Chemical engineering Mechanics of Materials Delayed-Action Preparations Triethoxysilane 0210 nano-technology medicine.drug |
| Zdroj: | Materials scienceengineering. C, Materials for biological applications. 85 |
| ISSN: | 1873-0191 |
| Popis: | This study presents an interesting and promising strategy for producing an oral multiparticulate formulation of the sustained-release of diclofenac sodium (DS) consisting of subunits closed inside hard gelatin capsules (each capsule contains ~50mg of diclofenac sodium). The subunits in the form of beads were produced through the encapsulation of diclofenac sodium dispersed within a nondisintegrating polymer carrier by a silica gel functionalized with the 3-aminopropyl groups. The hybrid silica gel, which plays the role of enteric coating, was fabricated by the gelation of the liquid silica precursors mixture (i.e. tetraethoxysilane (TEOS) and (3-aminopropyl)triethoxysilane (APTES)) in the vapor phase of ammonia. The conducted studies reveal that the introduction of the hybrid silica gel into the solid DS dispersion facilitates prolonged release in the neutral environment of the intestine. Since the ability of the multiparticulate formulation to control the release of the drug depends on the properties of its subunits, studies involving the low temperature N2 sorption, DSC analysis together with spectroscopic techniques (XRD, SEM, 29Si MAS NMR) were conducted. |
| Databáze: | OpenAIRE |
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