Can the Reactivity to Chromate Be Changed in Patch Testing Using a Barrier Cream?
| Autor: | Bruze Magnus, Isaksson Marléne, Zimerson Erik, Lejding Tina, Engfeldt Malin, Mowitz Martin, Svedman Cecilia |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Chromium Male Protective capacity Petrolatum medicine.medical_treatment Skin Cream Barrier cream Dermatology Patch testing 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Humans Immunology and Allergy Medicine 030212 general & internal medicine Food science Hexavalent chromium Allergic contact dermatitis Sensitization Aged Aged 80 and over Chromate conversion coating business.industry Patch test Middle Aged Patch Tests medicine.disease medicine.anatomical_structure chemistry Dermatitis Allergic Contact Female business |
| Zdroj: | Dermatitis. 31:373-377 |
| ISSN: | 2162-5220 1710-3568 |
| DOI: | 10.1097/der.0000000000000539 |
| Popis: | The persistent, difficult-to-treat, allergic contact dermatitis from hexavalent chromium in European construction workers has diminished significantly since the legislative measurements that came into force in January 2005. However, sensitization to hexavalent chromium continues to be a problem. Barrier creams have been tried for various allergens with divergent results. Objective The aim of the study was to investigate the protective capacity of barrier cream candidates against hexavalent chromium in a patch test situation. Methods An experimental study was performed to investigate the reductive properties of glutathione and iron sulfate on the patch test reactivity in chromium-allergic individuals when exposed to hexavalent chromium. In this study, we also investigated the protective properties of a commercially available barrier cream. Conclusions A higher number of volunteers (16/18) showed reactions on the skin treated with the commercially available barrier cream, compared with the untreated skin (13/18) on test reading day 3/4 or day 7. The skin treated with petrolatum or Essex cream showed fewer and less prominent allergic reactions than the skin treated with the commercially available barrier cream. (Less) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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