Effect of two β-alanine dosing protocols on muscle carnosine synthesis and washout
| Autor: | Helen Anwander, Roland Kreis, Jacques Décombaz, Tania Buehler, Trent Stellingwerff, Chris Boesch, Andrea Egger |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Magnetic Resonance Spectroscopy Clinical Biochemistry Carnosine Placebo Biochemistry Muscle carnosine Placebos 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Double-Blind Method Internal medicine medicine Humans Dosing Muscle Skeletal 030304 developmental biology Alanine 0303 health sciences Dose-Response Relationship Drug Chemistry Organic Chemistry Washout Skeletal muscle 030229 sport sciences Dose–response relationship Endocrinology medicine.anatomical_structure Dietary Supplements beta-Alanine |
| Zdroj: | Stellingwerff, Trent; Anwander, Helen; Egger, Andrea; Buehler, Tania; Kreis, Roland; Decombaz, Jacques; Boesch, Chris (2012). Effect of two beta-alanine dosing protocols on muscle carnosine synthesis and washout. Amino acids, 42(6), pp. 2461-72. Wien: Springer 10.1007/s00726-011-1054-4 Amino acids |
| ISSN: | 1438-2199 0939-4451 |
| Popis: | Carnosine (β-alanyl-L-histidine) is found in high concentrations in skeletal muscle and chronic β-alanine (BA) supplementation can increase carnosine content. This placebo-controlled, double-blind study compared two different 8-week BA dosing regimens on the time course of muscle carnosine loading and 8-week washout, leading to a BA dose-response study with serial muscle carnosine assessments throughout. Thirty-one young males were randomized into three BA dosing groups: (1) high-low: 3.2 g BA/day for 4 weeks, followed by 1.6 g BA/day for 4 weeks; (2) low-low: 1.6 g BA/day for 8 weeks; and (3) placebo. Muscle carnosine in tibialis-anterior (TA) and gastrocnemius (GA) muscles was measured by 1H-MRS at weeks 0, 2, 4, 8, 12 and 16. Flushing symptoms and blood clinical chemistry were trivial in all three groups and there were no muscle carnosine changes in the placebo group. During the first 4 weeks, the increase for high-low (TA 2.04 mmol/kgww, GA 1.75 mmol/kgww) was ~twofold greater than low-low (TA 1.12 mmol/kgww, GA 0.80 mmol/kgww). 1.6 g BA/day significantly increased muscle carnosine within 2 weeks and induced continual rises in already augmented muscle carnosine stores (week 4-8, high-low regime). The dose-response showed a carnosine increase of 2.01 mmol/kgww per 100 g of consumed BA, which was only dependent upon the total accumulated BA consumed (within a daily intake range of 1.6-3.2 g BA/day). Washout rates were gradual (0.18 mmol/kgww and 0.43 mmol/kgww/week; ~2%/week). In summary, the absolute increase in muscle carnosine is only dependent upon the total BA consumed and is not dependent upon baseline muscle carnosine, the muscle type, or the daily amount of supplemented BA. |
| Databáze: | OpenAIRE |
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