Geographical distribution of Burkholderia pseudomallei in soil in Myanmar

Autor:	Aung Pyae Phyo, Joshua Cohen, Kyaw Thu Soe, Premjit Amorncha, Clare L. Ling, Frank Smithuis, Elizabeth A. Ashley, Myo Maung Maung Swe, Mo Mo Win, Thin Thin Wah, Kyi Kyi Nyein Win, Daniel M. Parker, Htet Naing Lin, David A. B. Dance
Přispěvatelé:	Torres, Alfredo G
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	0301 basic medicine Bacterial Diseases Veterinary medicine Atmospheric Science Melioidosis Burkholderia pseudomallei RC955-962 Monsoons Social Sciences Myanmar Pathology and Laboratory Medicine Medical and Health Sciences Geographical Locations 0302 clinical medicine Medical Conditions Arctic medicine. Tropical medicine Agricultural Soil Science Dry season Land Use Medicine and Health Sciences Soil Microbiology 2. Zero hunger Climatology biology Geography Soil classification Agriculture Biological Sciences Soil type 3. Good health Bacterial Pathogens Infectious Diseases Agricultural soil science Medical Microbiology Seasons Public aspects of medicine RA1-1270 Pathogens Research Article Asia Burkholderia 030106 microbiology 030231 tropical medicine Soil Science Human Geography Microbiology Vaccine Related 03 medical and health sciences Tropical Medicine Tropical monsoon climate medicine Humans Microbial Pathogens Bacteria Prevention Winter Public Health Environmental and Occupational Health Organisms Tropics Biology and Life Sciences 15. Life on land medicine.disease biology.organism_classification Climate Action People and Places Earth Sciences
Zdroj:	PLoS Neglected Tropical Diseases PLoS neglected tropical diseases, vol 15, iss 5 PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009372 (2021)
ISSN:	1935-2735 1935-2727
Popis:	Background Burkholderia pseudomallei is a Gram-negative bacterium found in soil and water in many tropical countries. It causes melioidosis, a potentially fatal infection first described in 1911 in Myanmar. Melioidosis is a common cause of sepsis and death in South and South-east Asia, but it is rarely diagnosed in Myanmar. We conducted a nationwide soil study to identify areas where B. pseudomallei is present. Methodology/Principal findings We collected soil samples from 387 locations in all 15 states and regions of Myanmar between September 2017 and June 2019. At each site, three samples were taken at each of three different depths (30, 60 and 90 cm) and were cultured for B. pseudomallei separately, along with a pooled sample from each site (i.e. 10 cultures per site). We used a negative binomial regression model to assess associations between isolation of B. pseudomallei and environmental factors (season, soil depth, soil type, land use and climate zones). B. pseudomallei was isolated in 7 of 15 states and regions. Of the 387 sites, 31 (8%) had one or more positive samples and of the 3,870 samples cultured, 103 (2.7%) tested positive for B. pseudomallei. B. pseudomallei was isolated more frequently during the monsoon season [RR-2.28 (95% CI: 0.70–7.38)] and less in the hot dry season [RR-0.70 (95% CI: 0.19–2.56)] compared to the cool dry season, and in the tropical monsoon climate zone [RR-2.26; 95% CI (0.21–6.21)] compared to the tropical dry winter climate zone. However, these associations were not statistically significant. B. pseudomallei was detected at all three depths and from various soil types (clay, silt and sand). Isolation was higher in agricultural land (2.2%), pasture land (8.5%) and disused land (5.8%) than in residential land (0.4%), but these differences were also not significant. Conclusion/Significance This study confirms a widespread distribution of B. pseudomallei in Myanmar. Clinical studies should follow to obtain a better picture of the burden of melioidosis in Myanmar. Author summary Melioidosis is caused by a soil dwelling bacterium called Burkholderia pseudomallei. It is a potentially fatal disease even if appropriate antibiotics are given. The disease was first described in Rangoon (now Yangon) in 1911 but it has rarely been reported in Myanmar over the past century even though it is now known to be a common cause of community-acquired infection in neighbouring countries in South and Southeast Asia. The true melioidosis burden in Myanmar is obscured by a lack of awareness among clinicians and limited diagnostic facilities to identify the causative organism. To explore this issue, we conducted a nationwide study to assess the presence of B. pseudomallei in soil samples collected from all fifteen states and regions of Myanmar. Our study revealed a widespread distribution of the organism in the Myanmar environment. This finding contributes to the understanding of the global distribution of B. pseudomallei and should alert clinicians throughout Myanmar to consider melioidosis as a potential cause of fever, sepsis, pneumonia and abscesses.
Databáze:	OpenAIRE
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