Malignant lymphoma in ferrets: Clinical and pathological findings in 19 cases
| Autor: | James G. Fox, Rebecca Rose, Frances M. Moore, Susan E. Erdman |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Pathology medicine.medical_specialty Enzyme-Linked Immunosorbent Assay Biology Antibodies Viral Pathology and Forensic Medicine Antigen immune system diseases hemic and lymphatic diseases medicine Animals Lymphocytes Aleutian disease Pathological Neoplasm Staging Atypical Lymphocyte CATS General Veterinary Incidence Lymphoblast Ferrets virus diseases Histology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Leukemia Lymphocytic Chronic B-Cell Lymphoma Immunology Female |
| Zdroj: | Journal of Comparative Pathology. 106:37-47 |
| ISSN: | 0021-9975 |
| Popis: | The clinical and pathological findings in 19 ferrets (Mustela putorius furo) with malignant lymphoma are reviewed. Peripubescent ferrets had rapidly progressive stage IV high grade immunoblastic or small non-cleaved cell lymphoma. Adult ferrets had stage II or IV low grade diffuse small lymphocytic (DSL) lymphoma, stage IV high grade small non-cleaved cell lymphoma, or stage IV high grade immunoblastic polymorphous (IBP) lymphoma. Three ferrets had concurrent IBP and DSL lymphoma involving different organs. The IBP admixture of immunoblasts, large atypical lymphocytes, Reed-Sternberg-like cells, lymphoblasts and small lymphocytes has been associated with certain retrovirally associated lymphomas and nodal hyperplasias in man, non-human primates and cats. Aleutian disease, a parvovirus-induced lymphoproliferative disease, also involves clinical and histological features similar to certain lymphomas in ferrets. Seven ferrets tested were seronegative for feline leukaemia virus antigen. Only one of eight ferrets was positive for Aleutian parvovirus antibody. The clinical and pathological findings are suggestive of a viral aetiology for certain lymphomas in ferrets. |
| Databáze: | OpenAIRE |
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