Recombinant-activated factor VII in patients with uncontrolled bleeding: A retrospective observational analysis
| Autor: | Said Abuhasna, Amer H Al Jundi, Hashem A Tarifi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Blood transfusion medicine.medical_treatment chemistry.chemical_compound Refractory Coagulopathy uncontrolled bleeding Immunology and Allergy Medicine Dosing Factor VII business.industry lcsh:RC633-647.5 Medical record Hematology lcsh:Diseases of the blood and blood-forming organs medicine.disease Surgery trauma chemistry Coagulation Anesthesia Hemostasis Original Article hemorrhage business recombinant-activated factor VIIa |
| Zdroj: | Asian Journal of Transfusion Science, Vol 6, Iss 1, Pp 14-18 (2012) Asian Journal of Transfusion Science |
| ISSN: | 1998-3565 0973-6247 |
| Popis: | Background: Factor VIIa (recombinant) has an off-label use to control life-threatening bleeding that is refractory to other measures and was shown to decrease transfusion requirements. Objective: The primary objective of this study was to assess the safety and effectiveness of factor VIIa (recombinant) on blood transfusion requirements and coagulation parameters when used in patients whose bleeding was uncorrected by other means. The pharmacoeconomic impact for any discrepancy from our protocol was evaluated. Secondary outcomes included 4-hour and 28-day mortality, as well as safety of this agent in terms of thromboembolic complications. Materials and Methods: We retrospectively evaluated patients who received recombinant-activated factor VII (rFVIIa) for uncontrolled bleeding from June 2008 to April 2011. The medical records of 33 patients were evaluated. Coagulation parameters and blood products were determined 24 hours before and 24 hours after administration of rFVIIa, and the results compared. Patients were also screened for any thromboembolic complications. Results: Administration of rFVIIa reduced blood transfusion requirements and improved coagulation parameters significantly (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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