Structural analogues of some highly active non-competitive AMPA antagonists
| Autor: | Istvan Tarnawa, Tamas Hamori, Ferenc Andrasi, Sandor Solyom, Pal Berzsenyi |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Patch-Clamp Techniques
Stereochemistry Clinical Biochemistry Pharmaceutical Science AMPA receptor Pharmacology Biochemistry Retina Brain Ischemia Benzodiazepines Mice Purkinje Cells Structure-Activity Relationship Drug Discovery Animals Humans Structure–activity relationship Receptors AMPA Patch clamp Molecular Biology Cells Cultured Electroshock Behavior Animal Chemistry Organic Chemistry Antagonist Biological activity Azepines Rats Anti-Anxiety Agents Molecular Medicine Anticonvulsants Non competitive Chickens |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 10:899-902 |
| ISSN: | 0960-894X |
| Popis: | Some 5-methyl analogues (14a-e) of the non-competitive AMPA antagonists 3-acylated 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-4,5-dihydro-3H-2,3-benzodi azepines (2,3) have been synthesized. Generally they show diminished or low biological activity but two derivatives (14a,b) reveal effects comparable to those of GYKI 52466 (1), the prototype non competitive AMPA antagonist. |
| Databáze: | OpenAIRE |
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