Streptozotocin-induced diabetes in the spontaneously hypertensive rat
| Autor: | Ravinder K. Saini, Hari Paul Singh, Alexander Rabinovitch, Pitambar Somani |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Streptozocin Diabetes Mellitus Experimental Endocrinology Spontaneously hypertensive rat Internal medicine Diabetes mellitus medicine Animals Insulin Pancreas business.industry Pancreatic insulin Body Weight nutritional and metabolic diseases Plasma glucose concentration Streptozotocin medicine.disease Rats Disease Models Animal Blood pressure Hypertension business medicine.drug |
| Zdroj: | Metabolism. 28:1075-1077 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/0026-0495(79)90144-6 |
| Popis: | Spontaneously hypertensive rats (SHR) were more sensitive to the diabetogenic effects of streptozotocin than normotensive Wistar-Kyoto (WKY) rats. Thus, 10 days after intravenous administration of 25 mg/kg streptozotocin in SHR, mean pancreatic insulin content was decreased by 42% (p less than 0.05), and mean plasma glucose concentration was increased from 85 to 215 mg/dl (p less than 0.001), whereas between 37.5 and 50 mg/kg of streptozotocin was required to produce similar effects in normotensive WKY rats. Also, there was a progressive decrease in blood pressure in SHR injected with 25, 35.7, or 50 mg/kg of streptozotocin, whereas blood pressure was progressively increased after streptozotocin in normotensive WKY rats. The opposite effects of streptozotocin-induced diabetes on blood pressure in SHR and WKY rats could be observed at similar degrees of hyperglycemia and are presently unexplained. |
| Databáze: | OpenAIRE |
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