First-phase insulin release during the intravenous glucose tolerance test as a risk factor for type 1 diabetes
| Autor: | Dolan Lm, Francine R. Kaufman, Chase Hp, Desmond A. Schatz, David Cuthbertson, Darrell M. Wilson, Jeffrey P. Krischer, Joseph I. Wolfsdorf, Neil H. White |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.medical_treatment Risk Factors Internal medicine Diabetes mellitus Insulin Secretion medicine Humans Insulin Risk factor Child Pancreatic hormone Glucose tolerance test Type 1 diabetes geography geography.geographical_feature_category medicine.diagnostic_test business.industry Autoantibody Glucose Tolerance Test Middle Aged medicine.disease Islet Diabetes Mellitus Type 1 Endocrinology Child Preschool Pediatrics Perinatology and Child Health business |
| Zdroj: | The Journal of Pediatrics. 138:244-249 |
| ISSN: | 0022-3476 |
| Popis: | To determine the relationship between first-phase (1 minute + 3 minutes) insulin production during the intravenous glucose tolerance test (IV-GTT) and risk factors for developing type 1 diabetes.Relatives of persons with type 1 diabetes (n = 59,600) were screened for islet cell antibodies (ICAs). Subjects who had positive screening results underwent IV-GTT (or =2 times), repeat ICA screening, insulin autoantibody (IAA) screening twice, and an oral glucose tolerance test.Of the 59,600 subjects in the study, 2199 (3.69%) had positive findings on initial ICA test. IV-GTTs were performed in 1622 subjects, with children8 years having the lowest first-phase insulin release (FPIR) and subjects 8 to 20 years of age having the highest FPIR. The FPIR was lower for subjects with a confirmed positive ICA test result or a positive IAA test result, subjects with higher titers of ICA or IAA, and subjects who had an abnormal (impaired or diabetic) oral glucose tolerance test result.FPIR in the IV-GTT correlates strongly with risk factors for development of type 1 diabetes. |
| Databáze: | OpenAIRE |
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