Comparison of Outpatient Nebulized vs Metered Dose Inhaler Terbutaline in Chronic Airflow Obstruction
| Autor: | Janet M. Copland, Christine F. McDonald, Hugh Mestitz |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.drug_class Terbutaline Critical Care and Intensive Care Medicine Random Allocation Route of administration Double-Blind Method Bronchodilator Administration Inhalation Ambulatory Care Humans Medicine Lung Diseases Obstructive Exercise Aged Dose-Response Relationship Drug business.industry Nebulizers and Vaporizers Inhaler Middle Aged Crossover study Metered-dose inhaler Asthma Bronchodilatation Nebulizer Spirometry Anesthesia Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Chest. 96:1237-1240 |
| ISSN: | 0012-3692 |
| Popis: | Eighteen patients (nine asthmatic patients and nine with poorly reversible airflow obstruction) with stable, severe chronic airflow obstruction, completed a four-week randomized, doubled-blind, placebo-control, crossover trial comparing the acute and chronic effects of terbutaline administered by metered-dose inhaler (MDI) and nebulizer (NEB). Equipotent doses of terbutaline were selected from the comparison of separate cumulative dose-response curves for MDI and NEB. The MDI and NEB given acutely produced similar bronchodilatation and improvement in exercise performance. Spirometric indices, 6 min walking distance, symptom scores and extra beta-agonist use were no different between MDI and NEB treatment fortnights in the outpatient study. We conclude that the degree of bronchodilatation achieved in these patients is a reflection of the dose of bronchodilator administered and not the mode of administration. There is no justification for the preferred outpatient use of nebulized bronchodilators in patients with stable chronic airflow obstruction who can use adequate doses of bronchodilators via a metered-dose inhaler. |
| Databáze: | OpenAIRE |
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