Regulatory role of adrenergic neurotransmitters on the spontaneous muscular activity in the ruminant trematode Paramphistomum cervi (Paramphistomatidae)
| Autor: | L.C. Lahon, Chandana Choudhury Barua, Pawan Kumar Verma, Snigdha Hazarika, Beenita Saikia, Rumi S. Borah, Deep Prakash Saikia |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Adrenergic beta-Antagonists Adrenergic Pharmacology Norepinephrine Ivermectin Adrenergic Agents Dopamine Internal medicine Pyrantel parasitic diseases medicine Helminths Animals Paramphistomum cervi Paramphistomatidae Neurotransmitter Agents biology Muscles General Medicine biology.organism_classification Endocrinology Epinephrine Dopamine Antagonists Animal Science and Zoology Parasitology Locomotion medicine.drug |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1475-2697 |
| Popis: | The neuromuscular system of helminths is an important area for target identification and drug development. Many anthelmintics, namely ivermectin, levamisole, piperazine, pyrantel, praziquantel and organophosphates, produce paralysis of helminths by affecting their neuromuscular systems. The neuromuscular system of helminths is also an important area of research to identify some of the important differences between the neuromuscular physiology of helminths and mammals. The identification of differences would help in developing newer target-specific, safe and effective anthelmintics. The present study was carried out to investigate the effects of different adrenergic neurotransmitters (epinephrine, norepinephrine, dopamine, l-dopa) and their antagonists (propranolol and haloperidol) on the spontaneous muscular activity of isometrically mounted Paramphistomum cervi. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|