Intestinal Inflammation and Impact on Growth in Children With Cystic Fibrosis
| Autor: | Adam Jaffe, Roxanne Strachan, Lily Nahidi, Steven T. Leach, Chee Y. Ooi, Jung M. Lee, Jasbir Dhaliwal, Tamara Pang, Tamarah Katz, Andrew S. Day |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Cystic Fibrosis Enzyme-Linked Immunosorbent Assay Growth Cystic fibrosis Gastroenterology Inflammatory bowel disease Feces fluids and secretions Crohn Disease Osteoprotegerin Nutritional Indices Intestinal inflammation Internal medicine medicine Humans Intestinal Mucosa Child Growth Disorders Inflammation Crohn disease business.industry S100A12 Protein medicine.disease Faecal calprotectin Child Preschool Pediatrics Perinatology and Child Health Immunology Exocrine Pancreatic Insufficiency Female Calprotectin business Leukocyte L1 Antigen Complex Biomarkers |
| Zdroj: | Journal of Pediatric Gastroenterology & Nutrition. 60:521-526 |
| ISSN: | 0277-2116 |
| Popis: | Objective: The aim of the study was to evaluate and compare faecal markers of intestinal inflammation in children with cystic fibrosis (CF), and determine whether intestinal inflammation adversely affects the nutritional phenotype. Methods: Faecal samples for markers of intestinal inflammation, calprotectin, S100A12, and osteoprotegerin, were collected from children with CF, healthy controls (HCs), and Crohn disease (CD). Associations between inflammatory markers and clinical and nutritional indices were determined in subjects with CF. Results: Twenty-eight children with CF (mean [standard deviation (SD)] 8.4 [3.3] years old, 22 pancreatic insufficient [PI]), 47 HC, and 30 CD were recruited. Mean (SD) faecal calprotectin in CF (94.3 [100.6] mg/kg) was greater than HC (26.7 [15.4] mg/kg, P < 0.0001), but lower than CD (2133 [2781] mg/kg, P ¼ 0.0003). Abnormal faecal calprotectin was found in subjects only with PI (17/22 (77%), P ¼ 0.001). There was no difference in faecal mean (SD) S100A12 (0.8 [0.9] vs 1.5 [2.2] mg/kg, P ¼ 0.14) and osteoprotegerin concentrations (72.7 [52.2] vs 62.5 [0.0] pg/mL, P ¼ 0.2) between CF and HC. Patients with CD had significantly elevated S100A12 and osteoprotegerin compared with CF and HC. Faecal calprotectin inversely correlated with both weight (r ¼� 0.5, P ¼ 0.003) and height z scores (r ¼� 0.6, P ¼ 0.002) in CF. Conclusions: The pattern of intestinal inflammation in CF is unique and distinct from inflammatory bowel disease, with elevated faecal calprotectin but normal faecal S100A12 and osteoprotegerin concentrations. The severity of intestinal inflammation, based on faecal calprotectin, significantly correlates with poor growth. |
| Databáze: | OpenAIRE |
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