Antiproliferative Effects of the Enantiomers of Flurbiprofen
| Autor: | E. David Murray, Youjiang Liu, Darko Kantoci, Resa L. Chase, David D. Quiggle, William J. Wechter, John D. Mccracken, Yoshimitzu Mineyama |
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| Rok vydání: | 1996 |
| Předmět: |
Peptic Ulcer
Colorectal cancer Flurbiprofen Labeling index Pharmacology Biology Ulcer index Rats Sprague-Dawley chemistry.chemical_compound Intestine Small medicine Sprague dawley rats Animals Cyclooxygenase Inhibitors Pharmacology (medical) Nonsteroidal Cell growth Anti-Inflammatory Agents Non-Steroidal Stereoisomerism musculoskeletal system medicine.disease Rats chemistry Biochemistry Female lipids (amino acids peptides and proteins) Enantiomer Cell Division medicine.drug |
| Zdroj: | The Journal of Clinical Pharmacology. 36:540-545 |
| ISSN: | 0091-2700 |
| DOI: | 10.1002/j.1552-4604.1996.tb05043.x |
| Popis: | Nonsteroidal antiinflammatory drugs (NSAIDs) are recognized for inhibiting growth of colon tumors in animal models, and for reducing the risk of colon cancer in humans. The mechanisms involved have not been established, but are thought to be related to reduced prostaglandin biosynthesis. The present study investigates the effect of COX-inhibiting and non-COX-inhibiting enantiomers of flurbiprofen on rat colonocyte proliferation. Intestinal ulceration was used as a surrogate indicator of COX inhibition. Sprague Dawley rats were treated orally with 6.3 mg/kg of R- or S-flurbiprofen or vehicle. Colonocyte labeling index and small bowel ulcer index were measured. R-flurbiprofen and S-flurbiprofen significantly reduced colonocyte labeling index, by 34% and 23% respectively, compared with vehicle. R-flurbiprofen caused minimal ulcer formation (4.48 mm 2 ) compared with S-flurbiprofen (94.4 mm 2 ). These findings suggest that R-flurbiprofen-mediated control of colonocyte proliferation is independent of prostaglandin biosynthesis. |
| Databáze: | OpenAIRE |
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