Nitric oxide controls the light adaptive chromatic difference in receptive field size of H1 horizontal cell network in carp retina
| Autor: | Syozo Yasui, Tetsuo Furukawa, Mustafa B.A. Djamgoz, Renata Petruv, Masahiro Yamada |
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| Rok vydání: | 2002 |
| Předmět: |
Nitroprusside
Carps Action Potentials Dark Adaptation Context (language use) Nitric Oxide Retina Nitric oxide chemistry.chemical_compound Optics Culture Techniques Reaction Time medicine Animals Nitric Oxide Donors Chromatic scale Carp Neurons biology Adaptation Ocular business.industry Chemistry General Neuroscience Retinal biology.organism_classification Electrophysiology medicine.anatomical_structure Receptive field S-Nitrosoglutathione Biophysics sense organs Nerve Net business Photic Stimulation |
| Zdroj: | Experimental Brain Research. 147:296-304 |
| ISSN: | 1432-1106 0014-4819 |
| DOI: | 10.1007/s00221-002-1216-4 |
| Popis: | In carp retina, the receptive field size of the H1-type horizontal cell (HC) network is known to be chromatically selective, as electrophysiological signals are generated by short-wavelength (SW) light stimuli, which spread much less than those for long-wavelength (LW). We have shown previously that the signalling mechanism underlying this chromatic difference operates only in the light-adapted retina and that it involves cGMP as an intermediary messenger. In the present study, the possible role of nitric oxide (NO) as such a control mechanism was investigated. Application of a NO donor (SNP or SNOG) to dark-adapted retinae produced a chromatic difference in the receptive field size, such as in the light-adapted state. This effect was due mainly to a reduction in the spread of signals generated by SW stimuli; LW signalling spread was not altered. No such effect was observed in light-adapted retinae where a chromatic difference in receptive field size was already present. On the other hand, application of the NO 'scavenger' haemoglobin to light-adapted retinae suppressed the chromatic difference. These results are consistent with NO being a light-adaptive retinal neuromodulator involved in the generation of the chromatic difference in H1 cell receptive field size. These results are discussed in the context of two different hypotheses. |
| Databáze: | OpenAIRE |
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