Successful response of severe neonatal gram-negative infection to treatment with aztreonam
| Autor: | A. Constantopoulos, G. Papoulias, H. Loupa, L. Thomaidou |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Urinary system Aztreonam Infant Premature Diseases chemistry.chemical_compound Internal medicine Sepsis Drug Discovery Gram-Negative Bacteria medicine Monobactam Humans Pharmacology (medical) Meningitis Intensive care medicine Pharmacology business.industry Infant Newborn General Medicine Bacterial Infections bacterial infections and mycoses medicine.disease Prognosis Infectious Diseases Oncology chemistry Urinary Tract Infections business medicine.drug |
| Zdroj: | Chemotherapy. 35 |
| ISSN: | 0009-3157 |
| Popis: | Aztreonam was administered to 25 neonates (16 term, 9 premature) with clinically and bacteriologically proved gram-negative infections. Ten patients had meningitis, 9 had septicemia and 6 had urinary tract infections. Patients were between 1 and 28 days of age. Aztreonam was administered intravenously in doses ranging from 40 to 120 mg/kg/day for 10-30 days, depending on the causative organism. All CSF, blood and urine cultures were sterile 48 h after drug treatment had begun. There was no incidence of bacteriologic relapse. Body temperature returned to normal in 96% of patients within 3-4 days of therapy. Aztreonam was well tolerated. One infant experience nausea and vomiting, but no patient was withdrawn from therapy due to adverse reactions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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