| Autor: |
Dimitrios Bampatsias, Ioannis Mavroeidis, Simon Tual-Chalot, Nikolaos I. Vlachogiannis, Francesca Bonini, Marco Sachse, Georgios Mavraganis, Alexia Mareti, Chrysoula Kritsioti, Ageliki Laina, Dimitrios Delialis, Giorgia Ciliberti, Kateryna Sopova, Aikaterini Gatsiou, Fabio Martelli, Georgios Georgiopoulos, Konstantinos Stellos, Kimon Stamatelopoulos |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Thrombosis and haemostasis. 122(11) |
| ISSN: |
2567-689X |
| Popis: |
Background The noncoding antisense transcript for β-secretase-1 (BACE1-AS) is a long noncoding RNA with a pivotal role in the regulation of amyloid-β (Aβ). We aimed to explore the clinical value of BACE1-AS expression in atherosclerotic cardiovascular disease (ASCVD). Methods Expression of BACE1-AS and its target, β-secretase 1 (BACE1) mRNA, was measured in peripheral blood mononuclear cells derived from 434 individuals (259 without established ASCVD [non-CVD], 90 with stable coronary artery disease [CAD], and 85 with acute coronary syndrome). Intima-media thickness and atheromatous plaques evaluated by ultrasonography, as well as arterial wave reflections and pulse wave velocity, were measured as markers of subclinical ASCVD. Patients were followed for a median of 52 months for major adverse cardiovascular events (MACE). Results In the cross-sectional arm, BACE1-AS expression correlated with BACE1 expression (r = 0.396, p Conclusion BACE1-AS is associated with the incidence and severity of ASCVD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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