Field effect in molecule-gated switches and the role of target-to-receptor size ratio in biosensor sensitivity
| Autor: | Paulo Roberto Bueno, Flávio C. Bedatty Fernandes, Beatriz L Garrote, Eduardo Maffud Cilli |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Heart Diseases
Biomedical Engineering Biophysics Field effect Biosensing Techniques 02 engineering and technology 01 natural sciences Redox Quantum capacitors Dengue Molecular transistor Electrochemistry Humans Molecule Sensitivity (control systems) Receptor Molecular electrochemistry Inflammation Chemistry 010401 analytical chemistry Parkinson Disease Electrochemical Techniques General Medicine 021001 nanoscience & nanotechnology Debye screening 0104 chemical sciences Redox switches Molecular targets Size ratio 0210 nano-technology Oxidation-Reduction Biosensor Thomas-Fermi screening Biomarkers Biotechnology |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2019-10-06T16:59:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-02-15 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) We demonstrated here that molecular redox films are electrochemical capacitive devices possessing specific field effect in which molecular moieties within films act as sensitive gates. We confirm that the field effect present in these redox switches is suitable in detecting, in a label-free manner (without needs of redox probe in the biological samples), biomarkers of essential importance for dengue, heart risks and inflammation, Parkinson's disease and tumors. Though the sensitiveness is high, it is governed by Thomas Fermi screening and thus depends on the target-to-receptor size ratio. Thus, we also demonstrated how this target-to-receptor size ratio affects the sensitivity. We concluded that the smaller the biological receptor the greater the sensitivity. Consequently, a larger molecular target associated with a smaller receptor provides a considerable (predictable) improvement of the sensitiveness. Institute of Chemistry São Paulo State University (UNESP Universidade Estadual Paulista), CP 355 Institute of Chemistry São Paulo State University (UNESP Universidade Estadual Paulista), CP 355 |
| Databáze: | OpenAIRE |
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