INHALATION OF POORLY SOLUBLE PARTICLES. II. INFLUENCE OF PARTICLE SURFACE AREA ON INFLAMMATION AND CLEARANCE
| Autor: | D. Buchanan, C. L. Tran, R. T. Cullen, Ken Donaldson, A. D. Jones, A. Searl |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Pathology medicine.medical_specialty Metabolic Clearance Rate Neutrophils Health Toxicology and Mutagenesis Inflammation Toxicology chemistry.chemical_compound Metabolic clearance rate Administration Inhalation medicine Animals Rats Wistar Lung Titanium Inhalation Dust respiratory system Rats respiratory tract diseases Barium sulfate medicine.anatomical_structure chemistry Body Burden Particle Lymph Nodes Lymph Barium Sulfate medicine.symptom |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1091-7691 0895-8378 |
| DOI: | 10.1080/08958370050166796 |
| Popis: | In this article the volumetric overload hypothesis, which predicts the impairment of clearance of particles deposited in the lung in terms of particle volume, is reevaluated. The degree to which simple expressions of retained lung burden explain pulmonary responses to overload was investigated using data from a series of chronic inhalation experiments on rats with two poorly soluble dusts, titanium dioxide and barium sulfate. The results indicated that the difference between the dusts in the level of inflammation and translocation to the lymph nodes could be explained most simply when the lung burden was expressed as total particle surface area. The shape of the statistical relationship for both lung responses indicated the presence of a threshold at approximately 200-300 cm(2) of lung burden. On the basis of this and other similar results, a hypothesis regarding a generic mechanism for the impairment of clearance and associated lung responses is proposed for such "low-toxicity" dusts. |
| Databáze: | OpenAIRE |
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