Chemoprevention by Hippophae rhamnoides: Effects on Tumorigenesis, Phase II and Antioxidant Enzymes, and IRF-1 Transcription Factor
| Autor: | Bandhuvula Padmavathi, A. Ramesha Rao, Virendra Singh, Rana P. Singh, Pramod C. Rath, Meenakshi Upreti |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Cancer Research Skin Neoplasms Antioxidant 9 10-Dimethyl-1 2-benzanthracene medicine.medical_treatment Glutathione reductase Medicine (miscellaneous) Antioxidants Superoxide dismutase Mice chemistry.chemical_compound Stomach Neoplasms Hippophae NAD(P)H Dehydrogenase (Quinone) medicine Animals Anticarcinogenic Agents Glutathione Transferase chemistry.chemical_classification Glutathione Peroxidase Nutrition and Dietetics Papilloma biology Plant Extracts Superoxide Dismutase Chemistry Glutathione peroxidase Hippophae rhamnoides Glutathione Catalase Phosphoproteins biology.organism_classification Ascorbic acid DNA-Binding Proteins Glutathione Reductase IRF1 Liver Oncology Biochemistry biology.protein Interferon Regulatory Factor-1 Phytotherapy |
| Zdroj: | Nutrition and Cancer. 51:59-67 |
| ISSN: | 1532-7914 0163-5581 |
| Popis: | Fruits or berries of Hippophae rhamnoides (sea buckthorn), a rich source of vitamins A, C, and E, carotenes, flavonoids, and microelements such as sulfur, selenium, zinc, and copper, are edible and have been shown to protect from atopic dermatitis, hepatic injury, cardiac disease, ulcer, and atherosclerosis. However, its mechanism of action is not clear. We show that Hippophae inhibits benzo(a)pyrene-induced forestomach and DMBA-induced skin papillomagenesis in mouse. This decrease in carcinogenesis may be attributed to the concomitant induction of phase II enzymes such as glutathione S-transferase and DT-diaphorase and antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase in the mouse liver. This was accompanied by a remarkable induction of the transcription factor interferon regulatory factor-1 in the Hippophae-treated liver. Our results strongly suggest that Hippophae fruit is able to decrease carcinogen-induced forestomach and skin tumorigenesis, which might involve up-regulation of phase II and antioxidant enzymes as well as DNA-binding activity of IRF-1, a known antioncogenic transcription factor causing growth suppression and apoptosis induction for its anticancer effect. |
| Databáze: | OpenAIRE |
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