Red rice koji extract alleviates hyperglycemia by increasing glucose uptake and glucose transporter type 4 levels in skeletal muscle in two diabetic mouse models
| Autor: | Hajime Suzuki, Keizaburo Ogata, Kai-Chun Cheng, Akio Inui, Shouichi Miyawaki, Akihiro Asakawa, Yumiko Yoshizaki, Takakazu Yagi, Kazunori Takamine, Koji Ataka, Ikuo Kato |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Glucose uptake medicine.medical_treatment 030209 endocrinology & metabolism lcsh:TX341-641 red rice koji streptozotocin Impaired glucose tolerance 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine plasma lipids medicine Glucose tolerance test 030109 nutrition & dietetics Nutrition and Dietetics biology medicine.diagnostic_test diabetes Chemistry Insulin Insulin tolerance test high fat diet Public Health Environmental and Occupational Health nutritional and metabolic diseases medicine.disease Endocrinology biology.protein GLUT2 Original Article lcsh:Nutrition. Foods and food supply GLUT4 Food Science |
| Zdroj: | Food & Nutrition Research Food & Nutrition Research, Vol 64, Iss 0, Pp 1-9 (2020) |
| ISSN: | 1654-661X |
| Popis: | Background Red rice koji (RRK), prepared by growing Monascus species on steamed rice, has been reported to lower blood glucose levels in diabetic animal models. However, the action mechanism is not yet completely understood. Objective The objective of this study was to examine the mechanism underlying the hypoglycemic action of RRK extract in two diabetic animal models: the insulin-deficiency mice, where the insulin deficiency was induced by streptozotocin (STZ), and insulin-resistance mice, where the insulin resistance was induced by a high-fat diet (HFD). Design Low (12.5 mg/kg body weight [BW]) and high (50.0 mg/kg BW) doses of RRK extract were orally administered to the mice for 10 successive days (0.25 mL/day/mouse). The protein expression levels of glucose transporter type 4 (GLUT4) in the skeletal muscle and glucose transporter type 2 (GLUT2) in the liver were measured. Blood glucose (BG) levels of STZ-treated mice in insulin tolerance test (ITT) and BG and insulin levels of HFD-fed mice in intraperitoneal glucose tolerance test (IPGTT) were investigated. Results In the STZ-treated mice, oral administration of RRK extract lowered BG levels and food intake but increased plasma 1,5-anhydroglucitol level. Moreover, the RRK extract lowered the BG levels of STZ-treated mice as measured by ITT. In the HFD-fed mice, we confirmed that the orally administered RRK extract lowered the BG and the homeostasis model assessment index for insulin resistance. Furthermore, the RRK extract lowered the BG and insulin levels of HFD-fed mice in IPGTT. Regarding the protein levels of GLUT, the orally administered RRK extract increased the GLUT4 level in the skeletal muscle; however, the RRK extract did not alter the GLUT2 level in the liver of either the STZ-treated or the HFD-fed mice. Discussion Our study demonstrates that RRK extract can improve impaired glucose tolerance in mouse models of diabetes by enhancing GLUT4 expression in skeletal muscle. Conclusion These results suggest that RRK extract could potentially be a functional food for the treatment of diabetes mellitus. |
| Databáze: | OpenAIRE |
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