Fecal Bile Acids Related to Small-Bowel Length before and after Ileal Exclusion
| Autor: | Tatu A. Miettinen, P. V. I. Koivisto, Matti Lempinen |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Cholesterol synthesis medicine.medical_specialty medicine.medical_treatment Familial hypercholesterolemia 030204 cardiovascular system & hematology Gastroenterology Steroid Bile Acids and Salts Hyperlipoproteinemia Type II Excretion Feces 03 medical and health sciences 0302 clinical medicine Ileum Internal medicine medicine Humans 030304 developmental biology 0303 health sciences Ileal bypass Chemistry Middle Aged medicine.disease Bile acid excretion Cholesterol Endocrinology Intestinal Absorption Female Bile acid synthesis |
| Zdroj: | Scandinavian Journal of Gastroenterology. 22:691-695 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.3109/00365528709011144 |
| Popis: | We studied the relationship among the small-bowel length, the fecal excretion of bile acids and neutral steroids, and cholesterol synthesis in 16 patients with familial hypercholesterolemia before and 1 month after the ileal bypass operation. The mean small-bowel length measured during the operation was 6.3 +/- 0.3 (SEM) m before and 4.3 +/- 0.2 m after the bypass of the distal third of the small bowel. The preoperative fecal bile acid excretion was negatively correlated (r = 0.63, p less than 0.01) with the small-bowel length, whereas this correlation was insignificant for fecal neutral steroid excretion and cholesterol synthesis. Postoperative amounts of fecal bile acids and neutral steroids and cholesterol synthesis were negatively correlated with the length of the small bowel remaining in function (r = -0.52, -0.51, and -0.62, respectively). Our study suggests that fecal bile acid excretion and, hence, bile acid synthesis are related to the small-bowel length even under physiologic conditions. |
| Databáze: | OpenAIRE |
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