Peripheral Inflammatory Cytokines and Lymphocyte Subset Features of Deceased COVID-19 Patients
| Autor: | Yaoyao Sun, Daoyuan Si, Yueying Wang, Nan Jiang, Yang Liu, Yang He, Qiong Yu, Piyong Ma, Mengdi Jin, Tianji Liu, Zhijun Li, Bo Yang, Jinnan Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male China Coronavirus disease 2019 (COVID-19) Article Subject T cell Cell Kaplan-Meier Estimate General Biochemistry Genetics and Molecular Biology Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine medicine Humans 030212 general & internal medicine B cell Aged Retrospective Studies B-Lymphocytes General Immunology and Microbiology business.industry SARS-CoV-2 COVID-19 Retrospective cohort study General Medicine Middle Aged medicine.disease Lymphocyte Subsets Peripheral Killer Cells Natural 030104 developmental biology medicine.anatomical_structure Immunology Medicine Cytokines Female business Cytokine storm Biomarkers Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2021 (2021) |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2021/9101082 |
| Popis: | Objective. To compare the difference of inflammatory cytokines and lymphocyte subsets between deceased patients and survivors with COVID-19. Methods. This retrospective study included 254 confirmed patients from 10 January to 11 March, 2020, at Tongji Hospital of Wuhan, China. Laboratory and immunologic features were collected and analyzed, and the main outcomes focused on inflammatory cytokines and lymphocyte subsets. Results. A trend of markedly higher levels of inflammatory cytokines as well as lower lymphocyte subset levels in deceased patients was observed compared with survivors. ROC curve analyses indicated that inflammatory cytokines and the decrease levels of T cell, Th (helper T cells) cell, Ts (suppressor T cells) cell, B cell, and NK cell along with Th/Ts ratio increase could be used to predict the death of COVID-19. Multivariate analyses showed that higher levels of IL-6, IL-8, and IL-10 remained significantly correlated with shorter survival time and that the amount of Ts cells was negatively associated with the possibility of death in COVID-19 patients. In conclusion, SARS-CoV-2 would cause lymphopenia and result in decreased lymphocyte subset cells, particularly in Ts cell counts, which further induces hyperinflammatory response and cytokine storm. IL-6, IL-8, IL-10, and Ts cell might be independent predictors for the poor outcome of COVID-19. |
| Databáze: | OpenAIRE |
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